Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice
Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice
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DOI：
10.1002/jnr.10013
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Parada, LF
中科院分区：
文献类型：
--
作者：
Kernie, SG;Erwin, TM;Parada, LF
神经干细胞在成年期的持续存在是近年来研究的热点。关于获得性脑损伤如何影响神经前体细胞增殖和重新填充损伤区域的能力的知识有限。在本研究中，我们利用成年小鼠创伤性脑损伤的受控皮质冲击模型和随后的BrdU标记来证明，在创伤性脑损伤的近端和远端区域，神经前体都有显著的增殖。损伤后60天，近端增殖几乎完全是星形胶质细胞，这表明新生成的细胞构成了大部分星形胶质瘢痕。此外，在远离损伤部位的区域，齿状回颗粒层内发生的神经发生水平是对照组的五倍以上。这些数据表明，神经增生在创伤性脑损伤后发生的重塑中起着关键作用，并提示了创伤性脑损伤后功能恢复如何在损伤后很长时间内持续发生的机制。(C) 2001 Wiley-Liss, Inc。
The persistence of neural stem cells into adulthood has been an area of intense investigation in recent years. There is limited knowledge about how an acquired brain injury might affect the ability of neural precursor cells to proliferate and repopulate injured areas. In the present study we utilize a controlled cortical impact model of traumatic brain injury in adult mice and subsequent BrdU labeling to demonstrate that there is significant proliferation of neural precursors in response to traumatic brain injury in areas both proximal and distal to the injury site. The fate of the proximal proliferation is almost exclusively astrocytic at 60-days post injury and demonstrates that newly generated cells make up much of the astrogilotic scar. Moreover, in areas more distal from the injury site, neurogenesis occurs within the granular layer of the dentate gyrus at a level more than five-fold greater than in controls. These data demonstrate that neural proliferation plays key roles in the remodeling that occurs after traumatic brain injury and suggests a mechanism as to how functional recovery after traumatic brain injuries continues to occur long after the injury itself. (C) 2001 Wiley-Liss, Inc.