Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis.
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis.
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DOI：
10.3389/fimmu.2018.00840
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发表时间：
2018
影响因子：
7.3
通讯作者：
Duerr CU
中科院分区：
文献类型：
--
作者：
Mindt BC;Fritz JH;Duerr CU
第2组先天性淋巴样细胞（ILC2）代表了一种进化上相当古老但最近才被鉴定的先天性淋巴样细胞家族成员，自2010年对其进行详细描述以来受到了广泛关注。它们可以协调先天性和适应性免疫反应，因为它们与几种免疫和非免疫细胞群相互作用并影响它们。此外，ILC2能够快速分泌大量的2型细胞因子，这些细胞因子可以有助于保护性但也有害的宿主免疫应答，这取决于时间、位置和生理环境。有趣的是，ILC2，尽管它们的稀缺性，是占主导地位的先天性淋巴样细胞群体在肺中，这表明了一个关键的作用，作为第一反应者和放大器后，在这个网站的免疫挑战。此外，最近描述的ILC2的组织驻留进一步强调了它们各自微环境的重要性。在这篇综述中，我们提供了肺生理学的概述，包括最突出的肺驻留细胞的描述，以及在这个独特的环境中已知的和潜在的ILC2相互作用的审查。我们将进一步概述最近的观察结果肺ILC2在免疫挑战，包括呼吸道感染，并讨论不同的模型和方法来研究ILC2在肺中的生物学。
Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they interact with and influence several immune and non-immune cell populations. Moreover, ILC2 are able to rapidly secrete large amounts of type 2 cytokines that can contribute to protective but also detrimental host immune responses depending on timing, location, and physiological context. Interestingly, ILC2, despite their scarcity, are the dominant innate lymphoid cell population in the lung, indicating a key role as first responders and amplifiers upon immune challenge at this site. In addition, the recently described tissue residency of ILC2 further underlines the importance of their respective microenvironment. In this review, we provide an overview of lung physiology including a description of the most prominent pulmonary resident cells together with a review of known and potential ILC2 interactions within this unique environment. We will further outline recent observations regarding pulmonary ILC2 during immune challenge including respiratory infections and discuss different models and approaches to study ILC2 biology in the lung.
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影响因子：
82.9
作者：
通讯作者：
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影响因子：
8.7
作者：
Bhakta NR;Woodruff PG
通讯作者：
Woodruff PG
影响因子：
82.9
作者：
通讯作者：
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影响因子：
14.2
作者：
Allakhverdi, Zoulfia;Comeau, Michael R.;Delespesse, Guy
通讯作者：
Delespesse, Guy
DOI：
10.1016/j.jaci.2014.11.037
发表时间：
2015-07
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Christianson CA;Goplen NP;Zafar I;Irvin C;Good JT Jr;Rollins DR;Gorentla B;Liu W;Gorska MM;Chu H;Martin RJ;Alam R
通讯作者：
Alam R