Asthma and allergic rhinitis at 4 years of age in relation to fish consumption in infancy
Asthma and allergic rhinitis at 4 years of age in relation to fish consumption in infancy
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DOI：
10.1081/jas-120018633
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发表时间：
2003-01-01
影响因子：
1.9
通讯作者：
Jaakkola, JJK
中科院分区：
文献类型：
--
作者：
Nafstad, P;Nystad, W;Jaakkola, JJK
有人建议，食用鱼和多不饱和脂肪酸可以对气道炎症和哮喘及其他过敏性疾病的发展具有保护作用。我们的目的是检验这一假设，即在生命的第一年食用鱼类可以降低儿童哮喘和过敏性鼻炎的风险。我们对2531名挪威儿童进行了一项为期4年的前瞻性队列研究，评估了出生后第一年饮食中引入鱼类与哮喘和过敏性鼻炎风险之间的关系。我们在logistic回归分析中估计了调整潜在混杂因素的比值比（OR）。47.6%的儿童在出生后1年内吃过鱼。过敏性鼻炎的校正OR为0.45（95%置信区间[CI] = 0.28，0.74），哮喘为0.84（95% CI = 0.57，1.22）。在生命的第一年食用鱼类可以降低儿童患哮喘和过敏性鼻炎的风险。
It has been suggested that consumption of fish and polyunsaturated fatty acids could have a protective effect against inflammation in the airways and the development of asthma and other allergic diseases. Our objective was to test the hypothesis that fish consumption during the first year of life decreases the risk of childhood asthma and allergic rhinitis. We assessed the relation between introduction of fish in the diet during the first year of life and risk of asthma and allergic rhinitis in a prospective 4-year cohort study of 2531 Norwegian children. We estimated odds ratios (OR) in logistic regression analysis adjusting for potential confounders. A total of 47.6% children had fish during the first year of life. The adjusted OR for allergic rhinitis was 0.45 (95% confidence interval [CI] = 0.28, 0.74) and for asthma 0.84 (95% CI = 0.57, 1.22). Fish consumption in the first year of life may reduce the risk of developing asthma and allergic rhinitis in childhood.