Overexpression of pituitary tumor transforming gene (PTTG) is associated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma
Overexpression of pituitary tumor transforming gene (PTTG) is associated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma
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DOI：
10.1016/j.acthis.2013.09.011
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Ma, Jianqun
中科院分区：
文献类型：
--
作者：
Zhang, Jinfeng;Yang, Yingnan;Ma, Jianqun
肿瘤转化基因（PTTG）是一种新发现的原癌基因，在人类肿瘤中异常表达。本研究旨在检测PTTG在食管鳞状细胞癌（ESCC）中的表达，并探讨其临床意义。采用免疫组化方法分析108例食管鳞癌石蜡包埋标本中PTTG蛋白表达与临床病理参数及预后的关系。38.0%（41/108）的食管鳞癌组织中PTTG过表达，PTTG的表达与食管鳞癌的分化程度、TNM分期、淋巴结转移、浸润深度有关（P< 0.05）。Kaplan-Meier曲线显示，与表达低水平PTTG的患者相比，肿瘤表达高水平PTTG的ESCC患者的总生存期显著缩短（P= 0.022，对数秩检验）。考克斯多因素回归分析显示PTTG过表达是影响食管鳞癌患者生存率的独立预后因素（危险比为2.35，P= 0.009）。总的来说，我们的数据表明，PTTG的过度表达可能有助于食管鳞癌的恶性进展，并作为一个新的预后指标与食管鳞癌患者。(C)2013 Elsevier GmbH. All rights reserved.
Pituitary tumor transforming gene (PTTG) is a newly identified proto-oncogene that has been shown to be aberrantly overexpressed in a subset of human cancers. The aim of the present study was to examine PTTG expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical significance. PTTG protein expression was analyzed in 108 archived, paraffin-embedded primary ESCC specimens by immunohistochemisty and correlated with clinicopathological parameters and patients' outcome. Overexpression of PTTG was observed in 38.0% (41/108) of primary ESCC tissues and significantly correlated with differentiation, TNM stage, lymph node metastasis, and depth of invasion (P< 0.05). Kaplan-Meier curves showed that ESCC patients with tumors expressing high levels of PTTG had substantially shorter overall survival compared with patients expressing low levels of PTTG (P= 0.022, log-rank test). Cox multivariate regression analysis revealed that overexpression of PTTG was an independent prognostic factor in overall survival for ESCC patients (hazard ratio was 2.35, P= 0.009). Overall, our data suggest that overexpression of PTTG may contribute to the malignant progression of ESCC and serve as a novel prognostic indicator for patients with ESCC. (C) 2013 Elsevier GmbH. All rights reserved.