Stimuli-responsive polymeric micelles for drug delivery and cancer therapy.
Stimuli-responsive polymeric micelles for drug delivery and cancer therapy.
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用于药物输送和癌症治疗的刺激响应聚合物胶束。
DOI：
10.2147/ijn.s158696
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发表时间：
2018
影响因子：
8
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Zhou Q;Zhang L;Yang T;Wu H
聚合物胶束（PM）由于其优异的理化性质、药物负载和释放能力、简便的制备方法、生物相容性和肿瘤靶向性，作为药物输送和癌症治疗的纳米载体被广泛研究。它们可以很容易地与各种功能部分进行工程设计，以进一步提高其在生物利用度、循环时间、肿瘤特异性和抗癌活性方面的性能。刺激敏感的PM能够响应各种细胞外和细胞内的生物刺激（例如，酸性pH、改变的氧化还原电位和上调的酶）以及外部人工刺激（例如，磁场、光、温度和超声），被认为是用于递送抗癌药物和/或成像剂的“智能”纳米载体，用于各种治疗和诊断应用。本文综述了用于药物输送、成像和癌症治疗的刺激响应性 PM 的最新进展。本文涵盖了刺激响应性 PM 的一般性，重点关注其主要传递策略和新兴技术/纳米材料，讨论了它们的缺点和局限性，并提供了它们的未来前景。
Polymeric micelles (PMs) have been widely investigated as nanocarriers for drug delivery and cancer treatments due to their excellent physicochemical properties, drug loading and release capacities, facile preparation methods, biocompatibility, and tumor targetability. They can be easily engineered with various functional moieties to further improve their performance in terms of bioavailability, circulation time, tumor specificity, and anticancer activity. The stimuli-sensitive PMs capable of responding to various extra- and intracellular biological stimuli (eg, acidic pH, altered redox potential, and upregulated enzyme), as well as external artificial stimuli (eg, magnetic field, light, temperature, and ultrasound), are considered as “smart” nanocarriers for delivery of anticancer drugs and/or imaging agents for various therapeutic and diagnostic applications. In this article, the recent advances in the development of stimuli-responsive PMs for drug delivery, imaging, and cancer therapy are reviewed. The article covers the generalities of stimuli-responsive PMs with a focus on their major delivery strategies and newly emerging technologies/nanomaterials, discusses their drawbacks and limitations, and provides their future perspectives.