REDUCED ACTIVITIES OF THIAMINE-DEPENDENT ENZYMES IN THE BRAINS AND PERIPHERAL-TISSUES OF PATIENTS WITH ALZHEIMERS-DISEASE
REDUCED ACTIVITIES OF THIAMINE-DEPENDENT ENZYMES IN THE BRAINS AND PERIPHERAL-TISSUES OF PATIENTS WITH ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1988.00520320022009
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发表时间：
1988-08-01
影响因子：
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通讯作者：
PERRINO, P
中科院分区：
文献类型：
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作者：
GIBSON, GE;SHEU, KFR;PERRINO, P
一份关于韦尼克-科尔萨科夫病患者的 Meynert 基底核细胞丢失的报告促使人们对阿尔茨海默病患者的大脑和外周组织中的焦磷酸硫胺素 (TPP) 依赖性酶进行了检查。在这些大脑中，2-酮戊二酸脱氢酶复合物的活性降低了 75% 以上，转酮醇酶的活性降低了 45% 以上。减少发生在组织学损伤和相对未损伤的区域。在红细胞和培养的成纤维细胞中发现了转酮酶的微小但具有统计学意义的异常，但 2-酮戊二酸脱氢酶复合物没有异常。先前的研究表明，大脑缺陷和外周组织对另一种 TPP 依赖性酶——丙酮酸脱氢酶复合物的不同影响。阿尔茨海默病患者的大脑以及某些外周组织中似乎缺乏 TPP 依赖性酶的活性。
A report of cell loss in the nucleus basalis of Meynert in patients with Wernicke-Korsakoff disease prompted the examination of thiamine pyrophosphate (TPP)-dependent enzymes in the brain and peripheral tissues of patients with Alzheimer''s disease. In these brains, the activities of the 2-ketoglutarate dehydrogenase complex were reduced more than 75% and those of transketolase more than 45%. Decreases occurred in histologically damaged and in relatively undamaged areas. Small but statistically significant abnormalities of transketolase, but not of 2-ketoglutarate dehydrogenase complex, were identified in red blood cells and cultured fibroblasts. Previous studies have shown deficiencies in the brain and variable effects in peripheral tissues on another TPP-dependent enzyme-the pyruvate dehydrogenase complex. Activities of TPP-dependent enzymes appear to be deficient in the brain and perhaps in some peripheral tissues in patients with Alzheimer''s disease.