IL-10 and TNF-α polymorphisms and the recovery from HCV infection
IL-10 and TNF-α polymorphisms and the recovery from HCV infection
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DOI：
10.1016/s0198-8859(03)00080-6
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发表时间：
2003-07-01
期刊：
影响因子：
2.7
通讯作者：
Almasio, PL
中科院分区：
文献类型：
--
作者：
Lio, D;Caruso, C;Almasio, PL
丙型肝炎病毒（HCV）感染成为慢性约85%的感染者，而只有15 - 96感染者自发清除病毒。可以想象，宿主的免疫遗传背景在恢复方面影响感染过程。因此，在这项研究中，我们评估了肿瘤坏死因子-α（TNF α，即，启动子的nt-863和nt-308处的2个双等位基因多态性）和白细胞介素-10（IL-10）基因座（即，I启动子nt-1082处的双等位基因多态性），对HCV感染的清除。为了这个目的，我们比较了18个西西里岛的病人谁已经自发地从以前的HCV感染与42个西西里岛的病人与目前的HCV感染和135个西西里岛的健康患者。结果表明，在从HCV感染中恢复的患者中，-863CC TNF-α启动子基因型（参与这种促炎细胞因子的高产生）的频率降低，-1082GG IL-10启动子基因型（参与这种抗炎细胞因子的高产生）的频率增加。对TNF-α和IL-10基因型的联合评估显示，与持续性HCV感染患者相比，消退的HCV感染组中的11种抗炎基因型（低TNF/高IL-10产生者）显著增加。总的来说，我们的研究结果表明，基因决定的控制HCV诱导的炎症反应可能在解决HCV感染中发挥作用。D美国组织相容性和免疫遗传学学会，2003年。爱思唯尔公司出版
Hepatitis C virus (HCV) infection becomes chronic in about 85% of infected individuals, whereas only 15 96 of infected people clear spontaneously the virus. It is conceivable that the host immunogenetic background influences the course of infection in term of recovery. Thus, in this study we have evaluated the effect of functionally relevant polymorphisms at tumor necrosis factor-alpha (TNFalpha, i.e., 2 biallelic polymorphisms at nt -863 and nt-308 of the promoter) and interleukin-10 (IL-10) loci (i.e., I biallelic polymorphism at nt -1082 of the promoter), on the clearance of HCV infection. To this purpose, we compared 18 Sicilian patients who had spontaneously recovered from previous HCV infection with 42 Sicilian patients with current HCV infection and 135 Sicilian healthy patients. The results demonstrate a decreased frequency of the -863CC TNF-alpha promoter genotype (involved in high production of this pro-inflammatory cytokine) and an increased frequency of the -1082GG IL-10 promoter genotype (involved in high production of this anti-inflammatory cytokine) in patients recovered from HCV infection. The evaluation of combined TNF-alpha and IL-10 genotypes revealed a significant increase of the 11 anti-inflammatory genotype" (low-TNF/high-IL-10 producers) in resolved HCV infection group compared with patients with persistent HCV infection. On the whole, our findings suggest that a genetically determined control of the HCV-induced inflammatory response may play a role in the resolution of HCV infection. D American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.