Lymphocytic choriomeningitis virus-induced immune dysfunction: induction of and recovery from T-cell anergy in acutely infected mice.
Lymphocytic choriomeningitis virus-induced immune dysfunction: induction of and recovery from T-cell anergy in acutely infected mice.
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淋巴细胞脉络膜脑膜炎病毒引起的免疫功能障碍：急性感染小鼠 T 细胞无反应性的诱导和恢复。
DOI：
10.1128/jvi.68.12.8477-8480.1994
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发表时间：
1994
影响因子：
5.4
通讯作者：
Southern,PJ
中科院分区：
文献类型：
--
作者：
Butz,EA;Southern,PJ
淋巴细胞性脉络丛脑膜炎病毒急性感染免疫功能正常小鼠，可诱导强效细胞毒性t淋巴细胞反应，消除感染性病毒。同时，矛盾的是，淋巴细胞对有丝分裂原和其他感染因子的反应普遍受到抑制。感染小鼠的脾细胞在体外对有丝分裂刺激的反应中释放了大量的γ干扰素，但白细胞介素2和白细胞介素4的释放量与对照细胞相比都没有类似的升高。早期的t细胞受体-近端信号事件被发现是完整的，证实细胞是有活力的，并以适当的方式接受了有丝分裂刺激。如果T细胞在清除小鼠体内的病毒后几周不进行处理，急性感染的成年去胸腺小鼠与正常小鼠平行恢复了connaavin A反应性。因此，虽然急性淋巴细胞性脉络丛脑膜炎病毒感染在t细胞受体结扎时具有破坏增殖的作用，但这种状态只是暂时的。相比之下，来自持续感染的成年小鼠的T细胞显示出豆蛋白A反应性的长期改变。
Acute infection of immunocompetent mice by lymphocytic choriomeningitis virus induces a potent cytotoxic T-lymphocyte response that eliminates infectious virus. Concurrently and paradoxically, there is a general suppression of lymphocyte responses to mitogens and to other infectious agents. Splenocytes from infected mice released significant amounts of gamma interferon in response to mitogenic stimulation in vitro, but neither interleukin 2 nor interleukin 4 was similarly elevated relative to the amounts released by control cells. Early T-cell receptor-proximal signaling events were found to be intact, confirming that the cells were viable and had received the mitogenic stimuli in an appropriate manner. Acutely infected adult thymectomized mice regained concanavalin A responsiveness in parallel with euthymic mice, if T cells were left unmanipulated for several weeks after clearance of virus from the mice. Therefore, although acute lymphocytic choriomeningitis virus infection has the effect of disrupting proliferation when the T-cell receptor is ligated, this state is only temporary. In contrast, T cells from persistently infected adult mice reveal long-lasting alterations in concanavalin A responsiveness.