PREVALENCE AND FORMS OF NEUROPATHIC MORBIDITY IN 800 DIABETICS
PREVALENCE AND FORMS OF NEUROPATHIC MORBIDITY IN 800 DIABETICS
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DOI：
10.1007/bf02965972
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发表时间：
1994-03-01
影响因子：
2.1
通讯作者：
GEOGHEGAN, M
中科院分区：
文献类型：
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作者：
OHARE, JA;ABUAISHA, F;GEOGHEGAN, M
我们前瞻性地确定了800例糖尿病患者（336例1型糖尿病，464例2型糖尿病）在一年内各种形式的糖尿病神经病变的发病率。记录的症状为：足部疼痛/感觉异常、感觉丧失和不宁腿综合征。我们还记录了神经性溃疡、肌萎缩、足下垂和眼麻痹的患病率。记录的自主神经症状包括：阳痿、体位性低血压和腹泻。100名非糖尿病对照受试者报告的唯一症状是：2%的感觉丧失和7%的不宁腿综合征。在糖尿病患者中，13%存在疼痛/感觉异常，7%存在感觉丧失，2%存在神经性溃疡。糖尿病性肌萎缩（近端股神经病变）的患病率为0.8%，眼肌麻痹0.1%，腓神经麻痹0.1%。20%的患者出现勃起功能障碍，1%出现症状性体位性低血压，1%出现糖尿病腹泻。总的来说，22.9%的人口受到一个或多个由神经病变引起的问题的困扰。两组糖尿病患者的神经病变均与年龄较大（p < 0.001）和严重视网膜病变（p < 0.001）相关，1型糖尿病患者的神经病变与糖尿病病程、蛋白尿（p < 0.02）、高血压（p < 0.01）和缺血性心脏病（p < 0.02）相关。
We prospectively determined the prevalence of morbidity from the various forms of diabetic neuropathy over one year in a population of 800 patients with diabetes mellitus (336 type 1, 464 type 2 DM). Symptoms documented were: pain/paraesthesia in the feet, loss of feeling and the restless legs syndrome. We also documented the prevalence of: neuropathic ulcers, amyotrophy, foot drop, and oculomotor palsy. Autonomic symptoms documented were: impotence, postural hypotension and diarrhoea. The only symptoms reported by 100 non-diabetic control subjects were: loss of feeling in 2% and restless legs syndrome in 7%. In the diabetics; pain/paraesthesia was present in 13%, feeling loss in 7% and neuropathic ulcers in 2% . The prevalence of Diabetic amyotrophy (proximal femoral neuropathy) was 0.8%, oculomotor palsy 0.1% and peroneal nerve palsy 0.1%. Erectile impotence was present in 20%, symptomatic postural hypotension in 1% and diabetic diarrhoea in 1%. Overall; 22.9% of the population was afflicted by one or more problems resulting from neuropathy. Neuropathy was associated with older age (p < 0.001), and serious retinopathy (p < 0.001) in both groups of diabetics and with duration of diabetes, proteinuria (p < 0.02), hypertension (p < 0.01) and ischaemic heart disease (p < 0.02) in type 1 diabetics.