Association of serum ceruloplasmin level with obesity: some components of metabolic syndrome and high-sensitive C-reactive protein in Iran.
Association of serum ceruloplasmin level with obesity: some components of metabolic syndrome and high-sensitive C-reactive protein in Iran.
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DOI：
10.1155/2012/951093
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发表时间：
2012
影响因子：
3.3
通讯作者：
Maracy MR
中科院分区：
文献类型：
--
作者：
Safavi SM;Ziaei R;Maracy MR
背景肥胖相关代谢紊乱的机制之一是肥胖诱导的炎症。脂肪组织中产生的促炎细胞因子可增加肝脏合成炎症敏感性血浆蛋白（ISP），包括血浆铜蓝蛋白（Cp）。本研究旨在探讨血清Cp水平与肥胖的关系。方法.采用病例-对照研究设计，将61例BMI ≥ 25 kg/m2者（病例组）和61例BMI < 25 kg/m2者（对照组）纳入研究。检测两组患者的血清Cp、甘油三酯、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和hsCRP水平。结果所有受试者血清Cp水平与BMI之间均无显著相关性[OR：1.02（CI，0.967 ~ 1.07）]，病例组（β = 0.012，P = 0.86）和对照组（β = 0.49，P = 0.07）也无显著相关性。然而，在对照组中，这种正相关性是微不足道的。血清Cp水平与血清甘油三酯水平呈正相关。结论血清Cp水平与该组受试者的肥胖无关。在该组受试者中，没有基线变量可以预测肥胖，包括血清Cp水平、FBS、总胆固醇、LDL和HDL-胆固醇以及hsCRP。
Background. One of the mechanisms that has been suggested for obesity related metabolic disturbances is obesity-induced inflammation. Pro-inflammatory cytokines generated in adipose tissue can increase hepatic synthesis of inflammation-sensitive plasma proteins (ISPs) including ceruloplasmin (Cp). In this study we aimed to investigate the relation between serum Cp level and obesity. Methods. 61 persons with body mass index (BMI) ≥ 25 kg/m2 (case group) and 61 persons with BMI < 25 kg/m2 (control group) were included in this study with a case-control design. Serum Cp levels, triglyceride level, fating blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and hsCRP were measured in both groups. Results. We did not observe any significant association between serum Cp level and BMI in all subjects [OR: 1.02 (CI, 0.967 to 1.07)] and in case (β = 0.012, P = 0.86) and control groups (β = 0.49, P = 0.07) separately. However, in control group, this positive association was marginally significant. We found a positive correlation between serum Cp level and serum triglyceride level. Conclusion. Serum Cp level was not related to obesity in this group of subjects. None of the baseline variables could predict obesity in this group of subjects, including serum Cp level, FBS, total cholesterol, LDL and HDL- cholesterols and hsCRP.