Declining executive control in normal aging predicts change in functional status: The freedom house study
Declining executive control in normal aging predicts change in functional status: The freedom house study
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DOI：
10.1111/j.1532-5415.2004.52104.x
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发表时间：
2004-03-01
影响因子：
6.3
通讯作者：
Polk, MJ
中科院分区：
文献类型：
--
作者：
Royall, DR;Palmer, R;Polk, MJ
目的：评估执行控制功能（ECF）对功能状态的贡献。设计：3年纵向队列研究。设置：一个综合护理退休社区。参与者：547名非机构化的70岁老人。测量：简易精神状态检查（MMSE）和执行访谈（EXIT 25）。使用工具性日常生活活动（IADL）评估功能状态。建立MMSE、EXIT 25和IADL的潜伏生长曲线模型。IADL的变化率（Δ IADL）（根据基线IADL和认知进行校正）根据每项认知测量（根据基线认知进行校正）的变化率进行回归。模型还调整了基线年龄，护理水平，和共病diseases.RESULTS：基线测试分数在正常范围内，但平均EXIT 25分数达到受损范围的第二次随访。所有变量的基线平均值和斜率存在显著变异性。EXIT 25的变化率与DeltaIADL密切相关（r=-0.57，P
OBJECTIVES: To assess the contribution of executive control function (ECF) to functional status.DESIGN: Three-year longitudinal cohort study.SETTING: A comprehensive-care retirement community.PARTICIPANTS: Five hundred forty-seven noninstitutionalized septuagenarians.MEASUREMENTS: The Mini-Mental State Examination (MMSE) and Executive Interview (EXIT25). Functional status was assessed using instrumental activities of daily living (IADLs). Latent growth curves of MMSE, EXIT25, and IADL were modeled. The rate of change in IADLs (DeltaIADL), adjusted for baseline IADLs and cognition, was regressed on the rate of change in each cognitive measure (adjusted for baseline cognition). Models were also adjusted for baseline age, level of care, and comorbid illnesses.RESULTS: Baseline test scores were within normal ranges, but mean EXIT25 scores reached the impaired range by the second follow-up. There was significant variability around the baseline means and slopes for all variables. The rate of change in EXIT25 was strongly correlated with DeltaIADL (r=-0.57, P