Intestinal secretion after jejunal bypass in the ground squirrel.
Intestinal secretion after jejunal bypass in the ground squirrel.
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地松鼠空肠绕道术后的肠道分泌物。
DOI：
10.1152/ajpregu.1992.263.6.r1209
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Cooke,HJ
中科院分区：
文献类型：
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作者：
Carey,HV;Cooke,HJ
前一篇论文[H]。V. Carey, Am。[j] .动物生理学报，2013 (2):1 - 2,2 . [j] .动物生理学报，21(2):387 - 387,1992。在这里，我们研究了空肠旁路对松鼠肠道分泌能力的影响，这些松鼠要么保持活动并继续进食（ACT），要么被诱导冬眠（HIB）。与与管腔内容物接触的空肠段（假手术和连续的ACT段）相比，很少或没有暴露于管腔流的空肠段（所有来自HIB的节段和来自ACT的旁路节段）粘膜湿重减少。未暴露于腔内内容物的节段的组织电导较大。当反应归一化到浆膜表面积时，对粘膜下神经元或浆膜碳二醇的电刺激的短路电流（Isc）反应在未暴露于管腔内容物的节段中更大。对隐窝区分泌反应的正常化产生了类似的模式。Isc对反映电致Na+吸收的粘膜丙氨酸的反应在很少或没有暴露于腔内内容物的节段中最大。HIB和ACT鼠旁路段的组织湿重、电导和分泌反应基本一致。这些结果表明，肠道内容物直接影响空肠分泌能力。
The preceding paper [H. V. Carey, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1202-R1208, 1992] demonstrated that a 3-day fast or the extended fast of hibernation enhanced the chloride secretory responses to a variety of agonists in the ground squirrel jejunum. Here we examined the effect of jejunal bypass on intestinal secretory capacity in squirrels that either remained active and continued to feed (ACT), or were induced to hibernate (HIB). Mucosal wet weights were reduced in jejunal segments that had little or no exposure to the luminal stream (all segments from HIB and bypassed segments from ACT) compared with segments in contact with luminal contents (sham and in continuity segments of ACT). Tissue conductances were greater in those segments not exposed to luminal contents. Short-circuit current (Isc) responses to electrical stimulation of submucosal neurons, or to serosal carbachol, were greater in segments not exposed to luminal contents when responses were normalized to serosal surface area. Normalization of secretory responses to crypt area produced a similar pattern. Isc responses to mucosal alanine, which reflect electrogenic Na+ absorption, were greatest in segments with little or no exposure to luminal contents. Tissue wet weights, conductances and secretory responses of bypassed segments of HIB and ACT squirrels were always similar. These results suggest that luminal contents directly influence jejunal secretory capacity.