Template-based protein modeling: recent methodological advances.
Template-based protein modeling: recent methodological advances.
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DOI：
10.2174/156802610790232314
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发表时间：
2010
影响因子：
3.4
通讯作者：
Doerksen RJ
中科院分区：
文献类型：
--
作者：
Daga PR;Patel RY;Doerksen RJ
蛋白质建模在药物发现和计算生物学中一直是一个非常具有挑战性的问题。最新的进展和计算能力的进步在很大程度上帮助解决了这个问题；然而，预测准确的蛋白质三维结构一直是一项复杂的任务。在蛋白质结构预测的两种常用方法中，基于模板的建模已经变得比从头建模更受欢迎。本文综述了近三年来比较蛋白质建模在方法学和理解方面的进展，包括同源搜索、折叠识别、二级结构预测、模型构建、环构建、侧链预测和模型质量评估。
Protein modeling has been a very challenging problem in drug discovery and computational biology. The latest advances and progress in computational power have helped to solve this problem to a considerable extent; however, predicting accurate three-dimensional structure of proteins has always been and remains a complicated assignment. Of the two common methods of protein structure prediction, template-based modeling has become more popular than ab initio modeling. In this review, we summarize the developments in methodology and of understanding for comparative protein modeling during the last three years, including for homologue search, fold recognition, secondary structure prediction, model building, loop building, side-chain prediction and model quality assessment.
影响因子：
3
作者：
Casbon JA;Saqi MA
通讯作者：
Saqi MA