Studies toward the total synthesis of garsubellin a:: A concise synthesis of the 18-epi-tricyclic core
Studies toward the total synthesis of garsubellin a:: A concise synthesis of the 18-epi-tricyclic core
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DOI：
10.1021/ol0255965
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发表时间：
2002-03-07
期刊：
影响因子：
5.2
通讯作者：
Shibasaki, M
中科院分区：
文献类型：
--
作者：
Usuda, H;Kanai, M;Shibasaki, M
During studies directed toward the total synthesis of garsubellin A, a concise stereocontrolled synthesis of the 18-epi-tricyclic compound 3 was achieved. Key steps were a one-pot stereoselective construction of the bicyclic lactone 23 followed by a formal migration to the bicyclo-[3.3.1]nonane-1,3,5-trione and an intramolecular Wacker-type tetrahydrofuran ring formation.
