CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.
CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.
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CD110 促进胰腺癌进展，其表达与不良预后相关。
DOI：
10.1007/s00432-019-02860-z
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Nakamura M
中科院分区：
文献类型：
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作者：
Yan Z;Ohuchida K;Zheng B;Okumura T;Takesue S;Nakayama H;Iwamoto C;Shindo K;Moriyama T;Nakata K;Miyasaka Y;Ohtsuka T;Mizumoto K;Oda Y;Hashizume M;Nakamura M
目的探讨CD 110在胰腺癌中的表达及其意义。方法采用免疫组织化学方法检测86例胰腺癌组织中CD 110的表达。我们评估了临床结果和其他临床病理因素，以确定CD 110对生存和肝转移的意义。我们在体外和体内研究了癌细胞外渗中的血小板生成素-CD 110信号传导。结果CD 110表达与低组织学分级浸润性导管癌相关，CD 110高表达患者预后较差（P= 0. 0003）。CD 110高表达是肝转移的独立预测因子（P= 0.0422）。敲低CD 110表达显著减弱细胞迁移和侵袭。血小板生成素治疗促进胰腺癌细胞外渗。在血小板生成素存在下，CD 110通过激活ERK-MYC信号通路增加细胞活力。结论CD 110表达下调可促进胰腺癌的进展，并可作为胰腺癌肝转移的预测因子。
PurposeThis study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.MethodsWe performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. We examine thrombopoietin–CD110 signaling in cancer cell extravasation in vitro and in vivo. We investigated the effects of CD110 knockdown on liver metastasis in a splenic xenograft mouse model.ResultsCD110 expression in cancer cells was associated with low-histological-grade invasive ductal carcinoma, and patients with high CD110 expression had poorer prognosis (P= 0.0003). High CD110 expression was an independent predictor of liver metastasis (P= 0.0422). Knockdown of CD110 expression significantly attenuated cell migration and invasion. Treatment with thrombopoietin promoted pancreatic cancer cell extravasation. In the presence of thrombopoietin, CD110 increased cell viability through the activation of the ERK–MYC signaling pathway. Knockdown of CD110 expression inhibited liver metastases in the mouse model.ConclusionsCD110 promotes pancreatic cancer progression and it may serve as a predictive factor for liver metastasis.