Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
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DOI：
10.1007/s00213-007-0952-3
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Krishnan-Sarin, Suchitra
中科院分区：
文献类型：
--
作者：
McKee, Sherry A.;O'Malley, Stephanie S.;Krishnan-Sarin, Suchitra
尼古丁替代通常用于治疗重度饮酒吸烟者的烟草使用。然而，很少有研究探讨尼古丁替代对酒精和饮酒行为的主观和生理反应的影响。一项双盲研究旨在检查经皮尼古丁替代品（0 mg对21 mg/天）改变对低剂量启动饮料的反应和随后的随意饮酒行为。寻求治疗的非依赖性重度饮酒者，他们每天吸烟。透皮贴剂贴敷后6小时，评估对预充饮料[旨在将血液酒精水平（巴尔斯）提高至0.03 g/dl]的主观和生理反应。随后是2小时的自我给药期，受试者可以选择消耗多达8种额外的饮料（每种设计使巴尔斯提高0.015 g/dl）或接受货币强化，用于未消费的饮料。结果我们发现，贴片应用后6 h，与戒断缓解相关的烟草渴望减少，与安慰剂贴剂条件相比，活性贴剂条件下的收缩压和心率增加。与6小时的尼古丁剥夺相比，在活性尼古丁贴片条件下，响应于引发饮料的主观中毒减弱（即，安慰剂贴剂）。在自我管理期间，受试者有较长的时间lavelets开始喝酒，因此出现消耗较少的饮料时，管理的活性贴片相比，安慰剂patch.Conclusions在重度饮酒者，经皮尼古丁替代相比，轻度尼古丁剥夺衰减主观和生理酒精反应，并推迟开始饮酒。
Rationale Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior.Objective The primary aim of this within-subject, double-blind study was to examine whether transdermal nicotine replacement (0 mg vs 21 mg/day) altered response to a low-dose priming drink and subsequent ad libitum drinking behavior.Materials and methods Subjects (n = 19) were non-treatment-seeking, non-dependent heavy drinkers who were daily smokers. Six hours after transdermal patch application, subjective and physiological responses to a priming drink [designed to raise blood alcohol levels (BALs) to 0.03 g/dl] were assessed. This was followed by a 2-h self-administration period where subjects could choose to consume up to eight additional drinks (each designed to raise BALs by 0.015 g/dl) or to receive monetary reinforcement for drinks not consumed.Results We found that 6 h after patch application, tobacco craving associated with withdrawal relief was decreased, and systolic blood pressure and heart rate were increased in the active patch condition compared to the placebo patch condition. Subjective intoxication in response to the priming drink was attenuated in the active nicotine patch condition compared to 6 h of nicotine deprivation (i.e., placebo patch). During the self-administration period, subjects had longer latencies to start drinking and consequently appeared to consume fewer drinks when administered the active patch compared to the placebo patch.Conclusions In heavy drinkers, transdermal nicotine replacement compared to mild nicotine deprivation attenuated subjective and physiological alcohol responses and delayed the initiation of drinking.