Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans
Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans
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DOI：
10.1152/ajpheart.00751.2005
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发表时间：
2006-02-01
影响因子：
4.8
通讯作者：
Mayet, J
中科院分区：
文献类型：
--
作者：
Davies, JE;Whinnett, ZI;Mayet, J
使用同时压力和速度测量来估计人体单个部位的动脉波速度。美国生理学杂志心脏循环生理学290：H878-H885，2006年。首次发表于2005年8月26日; doi：10.1152/ajpheart.00751.2005。目前还不可能测量人体冠状动脉中的波速，因为血管太短，无法采用主动脉中使用的传统两点测量技术。本文提出了一种新的基于波强分析的方法，该方法可以求出单点的波速。我们将这种方法应用于主动脉，然后用它来推导在人体冠状动脉的波速首次。我们同时测量压力和多普勒速度与冠状动脉内导线在左主干，左前降支和回旋支，主动脉在14名受试者后，正常冠状动脉造影。然后，在10名受试者中，在冠状动脉内注射硝酸异山梨酯前后沿主动脉进行了沿着连续测量。在主动脉中通过两种方法推导出波速：1）双部位距离/时间方法（压力波形的脚到脚延迟）和2）使用同时压力和速度测量的新单点方法。冠状动脉波速度采用单点法计算。两种方法测得的波速相关性良好（r=0.72，P < 0.05）。冠状动脉波速度与主动脉波速度相关（r=0.72，P=0.002）。应用硝酸盐后，冠状动脉波速度下降43%：从16.4 m/s（95%可信区间12.6-20.1）降至9.3 m/s（95%可信区间6.5-12.0，P
Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol 290: H878-H885, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00751.2005.-It has not been possible to measure wave speed in the human coronary artery, because the vessel is too short for the conventional two-point measurement technique used in the aorta. We present a new method derived from wave intensity analysis, which allows derivation of wave speed at a single point. We apply this method in the aorta and then use it to derive wave speed in the human coronary artery for the first time. We measured simultaneous pressure and Doppler velocity with intracoronary wires at the left main stem, left anterior descending and circumflex arteries, and aorta in 14 subjects after a normal coronary arteriogram. Then, in 10 subjects, serial measurements were made along the aorta before and after intracoronary isosorbide dinitrate. Wave speed was derived by two methods in the aorta: 1) the two-site distance/time method (foot-to-foot delay of pressure waveforms) and 2) a new single-point method using simultaneous pressure and velocity measurements. Coronary wave speed was derived by the single-point method. Wave speed derived by the two methods correlated well (r=0.72, P < 0.05). Coronary wave speed correlated with aortic wave speed (r=0.72, P=0.002). After nitrate administration, coronary wave speed fell by 43%: from 16.4 m/s (95% confidence interval 12.6-20.1) to 9.3 m/s (95% confidence interval 6.5-12.0, P