DECREASE IN INTRAOCULAR PRESSURE IN MAN BY A CARBONIC ANHYDRASE INHIBITOR, DIAMOX - A PRELIMINARY REPORT
DECREASE IN INTRAOCULAR PRESSURE IN MAN BY A CARBONIC ANHYDRASE INHIBITOR, DIAMOX - A PRELIMINARY REPORT
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DOI：
10.1016/0002-9394(54)92027-9
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发表时间：
1954-01-01
影响因子：
4.2
通讯作者：
BECKER, B
中科院分区：
文献类型：
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作者：
BECKER, B
金赛最近报道了兔眼后腔中高浓度的碳酸氢盐。这一发现倾向于证实弗里登瓦尔德的假设，即电解质通过睫状体主动转移到眼睛中。碳酸酐酶，一种催化二氧化碳和碳酸氢盐快速相互转化的酶，还没有涉及到这种转移。然而，眼睛中碳酸氢盐的积累似乎使这种酶在房水的形成中起着至关重要的作用。最近发现了一些非常有效的碳酸酐酶抑制剂，这提示着人们应该探索这些药物对眼压和动态的影响。Diamoxt（2乙酰氨基- 1,3,4 -噻二唑-5磺酰胺）已被证明是一种有效的碳酸酐酶抑制剂，可安全给药。由于它能抑制肾小管对碳酸氢钠的再吸收，作为充血性心力衰竭患者的利尿剂，Diamox受到了相当大的关注。在实验动物中，它还能抑制胃和胰腺的分泌。
A remarkably high concentration of bicarbonate in the posterior chamber of the rabbit eye has been reported recently by Kinsey. l This finding tended to confirm Friedenwald’s’ hypothesis of an active transfer of electrolytes into the eye by the ciliary body. Carbonic anhydrase, the enzyme that catalyzes the rapid interconversions of carbon dioxide and bicarbonate, has not yet been implicated in this transfer. The accumulation of bicarbonate in the eye, however, would make it seem likely that such an enzyme plays an essential role in the formation of the aqueous humor. The recent availability of extremely potent carbonic anhyclrase inhibitors3 suggested an exploration of the effects of such agents on the intraocular pressure and dynamics. Diamoxt (2acetylamino-1, 3, 4_thiadiazole-5sulfonamide) has proved to be an effective inhibitor of carbonic anhydrase which can be administered with safety to human subjects. Since it inhibits renal tubular reabsorption of sodium bicarbonate, Diamox has received considerable attention as a diuretic for patients with congestive heart failure.” In experimental animals it also inhibits gastric” and pancreatic’secretion.