Whole Tooth Regenerative Therapy Using a Bioengineered Tooth Germ.
Whole Tooth Regenerative Therapy Using a Bioengineered Tooth Germ.
复制标题
使用生物工程牙胚的全牙再生疗法。
DOI：
10.1007/s40496-013-0004-5
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发表时间：
2014
影响因子：
--
通讯作者：
Tsuji T
中科院分区：
文献类型：
--
作者：
Nakajima K;Oshima M;Tsuji T
牙齿疾病，包括龋齿和牙周病，会导致口腔功能的根本问题，如发音，咀嚼和咬合，以及一般的健康问题。用于组织修复和全牙置换的牙齿再生疗法目前正在开发为新的治疗方法。作为生物工程器官替代的一种形式，全牙替代治疗被认为是下一代再生治疗的重要模型系统。我们最近报道了生物工程牙胚或成熟牙单位（包括生物工程牙和牙周组织）移植后的生物工程牙替换。全牙再生疗法有可能完全恢复牙齿功能，包括响应机械应力的咀嚼潜力和对有害刺激的感知潜力。在这篇综述中，我们描述了最近的研究结果和技术支持牙齿再生治疗。
Dental disorders, including dental caries and periodontal disease, can cause fundamental problems for oral functions, such as enunciation, mastication and occlusion, as well as general health issues. Tooth regenerative therapies for tissue repair and whole tooth replacement are currently being developed as novel treatment approaches. As a form of bioengineered organ replacement, whole tooth replacement therapy is considered an important model system for next-generation regenerative therapy. We recently reported bioengineered tooth replacements after transplantation of a bioengineered tooth germ or mature tooth unit comprising the bioengineered tooth and periodontal tissues. Whole tooth regenerative therapy has the potential to fully restore tooth function, including masticatory potential in response to mechanical stress and perceptive potential for noxious stimulation. In this review, we describe recent findings and technologies underpinning tooth regenerative therapy.