The stem cell compartment in human interfollicular epidermis
The stem cell compartment in human interfollicular epidermis
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DOI：
10.1016/s0923-1811(02)00003-8
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发表时间：
2002-04-01
影响因子：
4.6
通讯作者：
Watt, FM
中科院分区：
文献类型：
--
作者：
Watt, FM
在这篇综述中，我总结了我的实验室最近所做的工作，在这些工作中，我们一直在研究干细胞在人类毛囊间表皮中的分布以及在体外调节干细胞命运的因素。强调干细胞的非随机性分布，并建议β1整合素和Deltal在干细胞构型中发挥作用。在体外，β1整合素、Notch、c-Myc和β-catenin都调节干细胞隔间的大小，最近来自转基因小鼠的证据表明，它们在体内也是重要的。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
In this review, I summarise recent work from my laboratory in which we have been examining the distribution of stem cells in human interfollicular epidermis and the factors that regulate stem cell fate in vitro. The non-random distribution of stem cells is emphasised and beta1 integrins and Deltal are suggested to play a role in stem cell patterning. beta1 integrins, Notch, c-Myc and beta-catenin all regulate the size of the stem cell compartment in vitro and recent evidence from transgenic mice suggests that they are also important in vivo. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.