ACIDIC HYDROLYSIS OF DEOXYCYTIDINE AND DEOXYURIDINE DERIVATIVES - GENERAL MECHANISM OF DEOXYRIBONUCLEOSIDE HYDROLYSIS
ACIDIC HYDROLYSIS OF DEOXYCYTIDINE AND DEOXYURIDINE DERIVATIVES - GENERAL MECHANISM OF DEOXYRIBONUCLEOSIDE HYDROLYSIS
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DOI：
10.1021/bi00751a005
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发表时间：
1972-01-01
期刊：
影响因子：
2.9
通讯作者：
DANZIG, M
中科院分区：
文献类型：
--
作者：
SHAPIRO, R;DANZIG, M
Robert Shapirof 和 Melvyn Danzig J 摘要：在 pH 6 至 H0=—6 范围内，研究了脱氧胞苷和脱氧尿苷及其 5-溴和 5-甲基衍生物的酸性水解动力学。反应的 pH 速率曲线、取代基效应和其他参数与涉及核苷单双和双双形成、随后 TV-糖基键断裂的机制一致。另一种广泛接受的机制涉及糖环打开（初始 C-0
Robert Shapirof and Melvyn Danzig J abstract: The kinetics of the acidic hydrolyses of deoxycyti-dine and deoxyuridine, and their 5-bromo and 5-methyl deriv-atives have been studied, in the range pH 6 to H0=—6. The pH-rate profiles, substituent effects, and other parameters of the reactions are consistent with a mechanism involving the formation of mono- and dicationsof the nucleoside, followed by rupture of the TV-glycosyl bond. An alternative, widely accepted, mechanism involving sugar-ring opening (initial C-0