Effects of reduced discrete coupling on filament tension in excitable media
Effects of reduced discrete coupling on filament tension in excitable media
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DOI：
10.1063/1.3551500
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发表时间：
2011-03-01
期刊：
影响因子：
2.9
通讯作者：
Panfilov, Alexander V.
中科院分区：
文献类型：
--
作者：
Alonso, Sergio;Baer, Markus;Panfilov, Alexander V.
波在心脏中的传播具有离散性，因为它是由通过间隙连接的离散细胞间连接介导的。虽然离散性对二维平面行波和涡旋波（螺旋波）传播的影响已经研究过，但对三维涡旋波（涡旋波）可能产生的影响尚未探讨。在可激介质的一般模型中，我们研究了离散单元耦合对细丝动力学的影响。我们发现，胞间耦合的降低降低了涡旋波细丝的线张力，并可能在三维可激晶格中引起负细丝张力不稳定。(C) 2011年美国物理研究所。(doi: 10.1063/1.3551500)
Wave propagation in the heart has a discrete nature, because it is mediated by discrete intercellular connections via gap junctions. Although effects of discreteness on wave propagation have been studied for planar traveling waves and vortexes (spiral waves) in two dimensions, its possible effects on vortexes (scroll waves) in three dimensions are not yet explored. In this article, we study the effect of discrete cell coupling on the filament dynamics in a generic model of an excitable medium. We find that reduced cell coupling decreases the line tension of scroll wave filaments and may induce negative filament tension instability in three-dimensional excitable lattices. (C) 2011 American Institute of Physics. [doi:10.1063/1.3551500]