EFFECTS OF ALCOHOL-CONSUMPTION ON LIPOPROTEINS OF PREMENOPAUSAL WOMEN - A CONTROLLED DIET STUDY
EFFECTS OF ALCOHOL-CONSUMPTION ON LIPOPROTEINS OF PREMENOPAUSAL WOMEN - A CONTROLLED DIET STUDY
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DOI：
10.1161/01.atv.15.2.179
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发表时间：
1995-02-01
影响因子：
8.7
通讯作者：
TAYLOR, PR
中科院分区：
文献类型：
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作者：
CLEVIDENCE, BA;REICHMAN, ME;TAYLOR, PR
相当一部分美国女性饮酒，但酒精引起的女性脂蛋白变化的对照研究很少。在这项研究中，测量了饮酒（相当于每天两杯）对34名绝经前妇女脂蛋白谱的影响，同时控制了受试者的饮食和其他各种潜在的混杂变量，包括月经周期的阶段。采用交叉设计进行酒精和无酒精治疗，并在治疗第三个月的早期卵泡期采集血液样本。饮用酒精后，高密度脂蛋白胆固醇水平增加10%，低密度脂蛋白水平下降8%，脂蛋白(a)水平不变。高密度脂蛋白胆固醇的增加是由于高密度脂蛋白(2)和高密度脂蛋白(3)的增加，并且高密度脂蛋白颗粒的总体大小增加。含载脂蛋白（类人猿）A-I和apoA-II以及含apoA-I但不含apoA-II的HDL颗粒在酒精作用下升高。尽管这些观察结果仅限于月经周期的一个阶段，但酒精引起的脂蛋白变化与被认为可以预防冠心病的变化是一致的。
A substantial portion of American women consume alcohol, but controlled studies of alcohol-induced changes in lipoproteins of women are rare. In this study, the effects of alcohol consumption (equivalent to two drinks per day) on the lipoprotein profiles of 34 premenopausal women were measured while controlling subjects' diet and various other potentially confounding variables including phase of the menstrual cycle. Alcohol and no-alcohol treatments were administered in a crossover design, and blood samples were obtained during the early follicular phase of the third month of treatment. With alcohol, HDL cholesterol levels increased 10%, LDL levels decreased 8%, and levels of lipoprotein(a) were unchanged. The increase in HDL cholesterol was due to an increase in both HDL(2) and HDL(3), and the overall size of HDL particles was increased. HDL particles containing apolipoprotein (ape) A-I and apoA-II as well as those containing apoA-I but no apoA-II were elevated in response to alcohol. Although these observations are limited to a single phase of the menstrual cycle, the alcohol-induced changes in lipoproteins are consistent with changes that are thought to confer protection against coronary heart disease.