THE THERMAL CONDENSATION OF GLUTAMIC ACID AND GLYCINE TO LINEAR PEPTIDES
THE THERMAL CONDENSATION OF GLUTAMIC ACID AND GLYCINE TO LINEAR PEPTIDES
复制标题
DOI：
10.1021/ja01544a027
复制
发表时间：
1958-01-01
影响因子：
15
通讯作者：
FOX, SW
中科院分区：
文献类型：
--
作者：
HARADA, K;FOX, SW
尽管谷氨酸通过加热几乎完全转化为内内酰胺，但它会与许多氨基酸中的每一种进行共聚，产生线性肽。本文研究了反应条件对谷氨酸和甘氨酸共聚反应的影响。透析产物的平均分子量为11，000 - 20，000，也已在产率、氨基酸组成、N-末端氨基酸组成和红外吸收光谱方面进行了表征。未取代氨基酸的加热通常产生二酮哌嗪、脱羧产物和焦油，而不是线性肽。2-4在几乎所有的情况下，这样的实验都是用单个氨基酸进行的。然而，当氨基酸通过加热进行共聚时，5通常由氨基酸产生线性肽，当单独加热时不能产生肽。6持续的研究揭示了不同氨基酸组合的不同行为模式。本文叙述了谷氨酸和甘氨酸共聚物的形成，
Although glutamic acidis convertedby heat virtually entirely to the inner lactam, it undergoes copolymerization with each of many amino acidsto yield linear peptides. The effects of conditions of reaction have been studiedfor the copolymerization of glutamic acid and glycine. The dialyzed products, of average molecular weight 11,000-20,000, have also been characterized in yield, amino acid composition, N-terminal amino acid composition and infrared absorption spectra.The heating of unsubstituted amino acids has typically yielded diketopiperazines, decarboxylation products and tars rather than linear peptides. 2-4 Such experiments have been carried out with single amino acids in almost all cases. When, however, amino acids are copolymerized by heat, 5 there often result linear peptides from amino acids which fail to yield peptides when heated individ-ually. 6 Continuing investigation reveals differ-ent patterns of behavior for different combinations of amino acids. In this paper is described the formation of copolymers of glutamic acid and gly-