Focused proton beam generating pseudo Bragg peak for FLASH therapy
Focused proton beam generating pseudo Bragg peak for FLASH therapy
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DOI：
10.1016/j.nima.2022.166618
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Z. Mei;Yi Yuan;Jian Wang;Danlei Fan;Kehan Li;Jinfeng Yang;K. Fan;M. Fan
中科院分区：
文献类型：
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作者：
Z. Mei;Yi Yuan;Jian Wang;Danlei Fan;Kehan Li;Jinfeng Yang;K. Fan;M. Fan
FLASH效应是指超高剂量率和超快照射，可以减少正常组织的损伤，同时保持肿瘤控制。等离子体质子回旋加速器可以产生高强度的连续束，使其成为潜在的FLASH质子治疗的理想选择。然而，产生剂量布拉格峰需要能量降能器，导致剂量率急剧下降，这对于FLASH治疗是不够的。本文提出了一种通过放弃能量降能器来显著提高光束强度的穿透光束模式。然而，这导致总路径剂量过高而无法接受。我们研究使用聚焦质子束集中到一个小的目标体积的剂量，形成一个伪布拉格峰剂量分布。模拟结果表明，当向靶体积输送相同剂量时，与原始平行射束相比，它可以显著降低积分入射和出射剂量，从而保护周围的健康组织。
FLASH effect refers to ultra-high dose rates and ultra-fast irradiation that could reduce normal tissue damage while maintaining tumor control. An isochronous proton cyclotron can generate high-intensity continuous beams, making it ideal for potential FLASH proton therapy. However, generating the dose Bragg peak requires an energy degrader, leading to a drastic decrease in dose rate that is inadequate for FLASH therapy. This paper proposes a shoot-through beam modality by abandoning the energy degrader to increase beam intensity significantly. However, this results in the overall path dose being too high to be accepted. We investigate using focused proton beams to concentrate the dose into a small target volume to form a pseudo-Bragg-peak dose distribution. Simulations show that it can significantly reduce the integrated entrance and exit dose compared to the original parallel beam when delivering the same dose to the target volume, sparing the surrounding healthy tissue.