Investigation of chromosome Y loss in men with schizophrenia.
Investigation of chromosome Y loss in men with schizophrenia.
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DOI：
10.2147/ndt.s172886
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发表时间：
2018
影响因子：
3.2
通讯作者：
Sora I
中科院分区：
文献类型：
--
作者：
Hirata T;Hishimoto A;Otsuka I;Okazaki S;Boku S;Kimura A;Horai T;Sora I
精神分裂症患者的预期寿命比一般人群低10-20年。此外，与女性相比，男性精神分裂症患者的发病年龄更早，缺陷症状更明显，病程更差，对抗精神病药物的反应更差。最近的研究表明，外周血中Y染色体（LOY）的丢失与全因死亡的风险增加有关。为了阐明男性特异性特征的病理生理学，我们研究了LOY和精神分裂症之间的关联。本研究包括360名日本男性（146名精神分裂症患者vs 214名对照）。Y染色体的相对量定义为基于来自Y-X同源釉原蛋白基因（AMELY和AMELX）的共扩增短序列的荧光信号的Y染色体与X染色体的比率（Y/X比率）。精神分裂症组LOY发生率与对照组无显著性差异。然而，在控制年龄和吸烟状况后，精神分裂症组中较长的病程与LOY相关（P=0.007，OR =1.11 [95%CI =1.03-1.19]）。根据我们的研究结果，精神分裂症可能对血液LOY没有显着的影响，但LOY可能与精神分裂症患者的病程有关。
Life expectancy is 10–20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03–1.19]). According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia.