Rapid diagnostic testing for malaria
Rapid diagnostic testing for malaria
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DOI：
10.1046/j.1365-3156.2003.01115.x
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发表时间：
2003-10-01
影响因子：
3.3
通讯作者：
Wongsrichanalai, C
中科院分区：
文献类型：
--
作者：
Murray, CK;Bell, D;Wongsrichanalai, C
开发了疟疾快速诊断设备(MRDD)，希望它们能提供准确、可靠、快速、廉价和易于获得的传统疟疾诊断方法的替代品。早期疟疾快速诊断研究的结果是非常有希望的，特别是在检测恶性疟原虫密度超过100-500个寄生虫/毫升时。尽管这些设备在十多年前就已经引入，但只引入了几个靶抗原。更令人担忧的是，这些设备在灵敏度、区分物种的能力和在热带野外条件下的稳定性方面存在局限性。最近的试验表明，无论是在产品内部还是在产品之间，敏感性都存在很大的差异。我们回顾了最近在流行和非流行国家评估MRDD用于诊断恶性疟原虫和非恶性疟原虫感染的试验，并描述了这些设备需要进一步改进的各个方面。由于针对新出现的多药耐药，以成本更高和毒性增加为特征的新的抗疟疾方案已被更广泛地采用，迫切需要高质量、准确、快速和负担得起的诊断工具。
Malaria rapid diagnostic devices (MRDD) have been developed with the hope that they would offer accurate, reliable, rapid, cheap and easily available alternatives to traditional methods of malaria diagnosis. The results from early malaria rapid diagnostic studies were quite promising, especially for detecting Plasmodium falciparum at densities of more than 100-500 parasites/mul. Despite the introduction of these devices over a decade ago, only a few target antigens have been introduced. Of greater concern, these devices have shown limitations in sensitivity, ability to differentiate species and robustness under field conditions in the tropics. Recent trials have revealed wide variability in sensitivity both within and between products. We review the recent trials assessing MRDD use for the diagnosis of P. falciparum and non- P. falciparum infections in endemic and non- endemic countries and describe the various aspects of these devices which need further improvement. High quality, accurate, rapid and affordable diagnostic tools are urgently needed now that new antimalarial regimens, characterized by higher cost and increased toxicity, have been introduced more widely in response to emerging multi-drug resistance.