Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome
Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome
复制标题
骨化三醇减轻多囊卵巢综合征小鼠模型的心脏重塑和功能障碍
DOI：
10.1007/s12020-015-0797-1
复制
发表时间：
2016-05-01
期刊：
影响因子：
3.7
通讯作者：
Huang, He-Feng
中科院分区：
文献类型：
--
作者：
Gao, Ling;Cao, Jia-Tian;Huang, He-Feng
Polycystic ovary syndrome (PCOS) is a complex reproductive and metabolic disorder affecting 10 % of reproductive-aged women, and is well associated with an increased prevalence of cardiovascular risk factors. However, there are few data concerning the direct association of PCOS with cardiac pathologies. The present study aims to investigate the changes in cardiac structure, function, and cardiomyocyte survival in a PCOS model, and explore the possible effect of calcitriol administration on these changes. PCOS was induced in C57BL/6J female mice by chronic dihydrotestosterone administration, as evidenced by irregular estrous cycles, obesity and dyslipidemia. PCOS mice progressively developed cardiac abnormalities including cardiac hypertrophy, interstitial fibrosis, myocardial apoptosis, and cardiac dysfunction. Conversely, concomitant administration of calcitriol significantly attenuated cardiac remodeling and cardiomyocyte apoptosis, and improved cardiac function. Molecular analysis revealed that the beneficial effect of calcitriol was associated with normalized autophagy function by increasing phosphorylation levels of AMP-activated protein kinase and inhibiting phosphorylation levels of mammalian target of rapamycin complex. Our findings provide the first evidence for the presence of cardiac remodeling in a PCOS model, and vitamin D supplementation may be a potential therapeutic strategy for the prevention and treatment of PCOS-related cardiac remodeling.
