MULTIDRUG-RESISTANCE GENE (P-GLYCOPROTEIN) IS EXPRESSED BY ENDOTHELIAL-CELLS AT BLOOD-BRAIN BARRIER SITES
MULTIDRUG-RESISTANCE GENE (P-GLYCOPROTEIN) IS EXPRESSED BY ENDOTHELIAL-CELLS AT BLOOD-BRAIN BARRIER SITES
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DOI：
10.1073/pnas.86.2.695
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发表时间：
1989-01-01
影响因子：
11.1
通讯作者：
BERTINO, JR
中科院分区：
文献类型：
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作者：
CORDONCARDO, C;OBRIEN, JP;BERTINO, JR
在血脑和其他血组织屏障部位的人毛细血管内皮细胞表达P-糖蛋白，如针对人多药耐药基因产物的小鼠单克隆抗体所检测到的。内皮细胞表达的这种模式可能表明P-糖蛋白在调节某些分子进入中枢神经系统和其他解剖隔室（如睾丸）中的生理作用。这些组织限制了全身药物的使用，是已知的转移性癌症的药理学避难所。P-糖蛋白在脑和睾丸而不是其他组织的毛细血管内皮中表达（即，肾脏和胎盘）可能部分解释了这一现象，并可能在癌症化疗中具有重要意义。
Endothelial cells of human capillary blood vessels at the blood-brain and other blood-tissue barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against the human multidrug-resistance gene product. This pattern of endothelial cell expression may indicate a physiological role for P-glycoprotein in regulating the entry of certain molecules into the central nervous system and other anatomic compartments, such as the testes. These tissues, which limit the access of systemic drugs, are known pharmacologic sanctuaries for metastatic cancer. P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.