Tm3+-Sensitized NIR-II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding
Tm3+-Sensitized NIR-II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding
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DOI：
10.1002/anie.201903536
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发表时间：
2019-07-22
影响因子：
16.6
通讯作者：
Zhang, Fan
中科院分区：
文献类型：
--
作者：
Zhang, Hongxin;Fan, Yong;Zhang, Fan
第二近红外窗口(NIR-II)的活体荧光成像提供了组织深度穿透和高空间分辨率。在这里，我们提出了一种新型的Tm3+敏化的稀土纳米晶体，它位于NIR-II窗口中，同时具有激发和发射(1208 nm和1525 nm)，用于体内光学信息的存储和解码。利用可调谐的荧光寿命，相应地提高了光复用编码容量。将带有NIR-II荧光寿命复用编码的二维码的微型器件植入小鼠体内，并通过时间门控荧光成像技术成功解码。
In vivo fluorescence imaging in the second near-infrared window (NIR-II) affords deep-tissue penetration and high spatial resolution. Herein, we present a new type of Tm3+-sensitized lanthanide nanocrystals with both excitation (1208 nm) and emission (1525 nm) located in the NIR-II window for in vivo optical information storage and decoding. Taking advantage of the tunable fluorescence lifetimes, the optical multiplexed encoding capacity is enhanced accordingly. Micro-devices with QR codes featuring the NIR-II fluorescence-lifetime multiplexed encoding were implanted into mice and were successfully decoded through time-gated fluorescence imaging technology.