Whole-Genome Expression Plasticity across Tropical and Temperate Drosophila melanogaster Populations from Eastern Australia
Whole-Genome Expression Plasticity across Tropical and Temperate Drosophila melanogaster Populations from Eastern Australia
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DOI：
10.1093/molbev/msq197
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发表时间：
2011-01-01
影响因子：
10.7
通讯作者：
Begun, David J.
中科院分区：
文献类型：
--
作者：
Levine, Mia T.;Eckert, Melissa L.;Begun, David J.
空间变异选择的基因型特征在果蝇基因组中普遍存在。空间结构的适应性表型差异也很常见，特别是沿着新世界和澳大利亚纬度梯度。然而，在一个或多个环境中的基因表达变异的调查，在这些充分研究的人群是令人惊讶的有限。在这里，我们报告了在两种温度下饲养的热带和温带东澳大利亚种群的全基因组转录水平。正如预期的那样，大量的基因表现出地理来源依赖的表达可塑性。不太预期的是证据丰富的下调基因在温带和热带人口时，线饲养的温度不太常见的本地范围内遇到的，也就是说，在这两个气候地区的可塑性的“方向性”的显着差异的证据。我们还报告了小规模的“邻居效应”的证据，这些基因的重要地理来源依赖的可塑性，结果与高水平的进化一致，可能是基于染色质的基因调控在D范围扩展。黑腹种群
The genotypic signature of spatially varying selection is ubiquitous across the Drosophila melanogaster genome. Spatially structured adaptive phenotypic differences are also commonly found, particularly along New World and Australian latitudinal gradients. However, investigation of gene expression variation in one or multiple environments across these well-studied populations is surprisingly limited. Here, we report genome-wide transcript levels of tropical and temperate eastern Australian populations reared at two temperatures. As expected, a large number of genes exhibit geographic origin-dependent expression plasticity. Less expected was evidence for an enrichment of down-regulated genes in both temperate and tropical populations when lines were reared at the temperature less commonly encountered in the native range; that is, evidence for significant differences in a "directionality" of plasticity across these two climatic regions. We also report evidence of small scale "neighborhood effects" around those genes significant for geographic origin-dependent plasticity, a result consistent with the evolution of high level, likely chromatin based gene regulation during range expansion in D. melanogaster populations.