ANNEXIN-V FORMS CALCIUM-DEPENDENT TRIMERIC UNITS ON PHOSPHOLIPID-VESICLES
ANNEXIN-V FORMS CALCIUM-DEPENDENT TRIMERIC UNITS ON PHOSPHOLIPID-VESICLES
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DOI：
10.1016/0014-5793(92)80964-i
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发表时间：
1992-12-14
期刊：
影响因子：
3.5
通讯作者：
SEATON, BA
中科院分区：
文献类型：
--
作者：
CONCHA, NO;HEAD, JF;SEATON, BA
通过化学交联研究了膜联蛋白 V（一种钙依赖性磷脂结合蛋白）的四级结构。研究发现，只有当阴离子磷脂存在时，钙才会诱导三聚体、六聚体和更高聚集体的形成。寡聚化在与膜联蛋白-囊泡结合相同的条件下发生。提出了一种模型，其中细胞刺激导致钙诱导的内膜表面膜联蛋白 V 阵列的组织，从而改变渗透性和流动性等特性。
The quaternary structure of annexin V, a calcium-dependent phospholipid binding protein, was investigated by chemical cross-linking. Calcium was found to induce the formation of trimers, hexamers, and higher aggregates only when anionic phospholipids were present. Oligomerization occurred under the same conditions as annexin-vesicle binding. A model is proposed in which cell stimulation leads to calcium-induced organization of arrays of annexin V lining the inner membrane surface, thus altering properties such as permeability and fluidity.