Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study
Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study
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DOI：
10.1038/ejcn.2013.88
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发表时间：
2013-07-01
影响因子：
4.7
通讯作者：
Bjorck, I. M. E.
中科院分区：
文献类型：
--
作者：
Gunnerud, U. J.;Ostman, E. M.;Bjorck, I. M. E.
背景/目的：乳清蛋白具有促胰岛素分泌的特性，其作用似乎是由餐后血浆氨基酸（AA）反应介导的。目的是研究乳清摄入量和血，insulinaemic和血浆AA responses.SUBJECTS/METHODS之间可能的剂量反应关系：12名健康志愿者参加了这项研究。他们提供了三种乳清蛋白饮料，含有4.5，9或18克蛋白质作为随机顺序的早餐。所有膳食均含有25 g可用碳水化合物（葡萄糖）。结果：乳清蛋白摄入量与餐后高血糖、胰岛素血症及血浆氨基酸呈线性关系。两个最高剂量，18 g和9 g，显著降低餐后高血糖（0-120 min曲线下面积（iAUC）增加; P
BACKGROUND/OBJECTIVES: Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.SUBJECTS/METHODS: Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.RESULTS: Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P