Exploration of a Chiral Cobalt Catalyst for Visible-Light-Induced Enantioselective Radical Conjugate Addition
Exploration of a Chiral Cobalt Catalyst for Visible-Light-Induced Enantioselective Radical Conjugate Addition
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可见光诱导对映选择性自由基共轭加成的手性钴催化剂的探索
DOI：
10.1002/anie.201907478
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xiao wen-jing
中科院分区：
文献类型：
--
作者：
Zhang kai;Lu liang-qiu;Jia yue;Wang ying;Lu fu-dong;Pan fang-fang;Xiao wen-jing
可见光诱导的不对称合成技术的发展迫切需要能够耐受光化学反应的手性催化剂。目前，基于稀土金属和手性N4配体的手性八面体配合物已被报道。一种定义明确的手性CoII-络合物被证明是可见光诱导的烯酮与烷基和酰基的共轭加成的有效催化剂，以47-> 99%的产率提供合成价值的手性酮和1，4-二羰基化合物，e.r.高达97：3。
Chiral catalysts tolerating photochemical reactions are in great demand for the vast development of visible‐light‐induced asymmetric synthesis. Now, chiral octahedral complexes based on earth‐abundant metal and chiral N4ligands are reported. One well‐defined chiral CoII‐complex is shown to be an efficient catalyst in the visible‐light‐induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4‐dicarbonyls in 47–>99 % yields with up to 97:3 e.r.