Autonomic dysfunction and anemia in neurologic disorders
Autonomic dysfunction and anemia in neurologic disorders
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DOI：
10.1016/s0165-1838(96)00070-7
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发表时间：
1996-11-06
期刊：
影响因子：
--
通讯作者：
Ando, M
中科院分区：
文献类型：
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作者：
Ando, Y;Asahara, K;Ando, M
研究了自主神经功能障碍对家族性淀粉样变性多发性神经病(FAP)I型、自主神经紊乱和Shy-Drager综合征等多种神经系统疾病贫血的影响。作为对照，将肌萎缩侧索硬化症(ALS)患者的血象与上述神经系统疾病患者进行比较。ALS患者已知没有自主神经功能障碍。FAP和自主神经障碍患者表现出明显的贫血，与自主神经功能障碍的严重程度相当。Shy-Drager患者表现为轻度贫血。然而，在ALS患者中，即使在这种疾病的末期，也根本没有发现这种贫血。在自主神经症患者中，可识别出骨髓发育不良，这与先前在FAP患者中报道的数据非常一致。重组人促红细胞生成素改善了4例FAP患者的直立性低血压和贫血。这些结果表明，自主神经功能障碍可能与红细胞生成密切相关。
The effect of autonomic dysfunctions on anemia in various neurological disorders, such as familial amyloidotic polyneuropathy (FAP) Type I, pandysautonomia, and Shy-Drager syndrome was examined. As a control, hemograms of patients with amyotrophic lateral sclerosis (ALS), which is known to be free from autonomic dysfunction, was compared with patients with the above neurological disorders. FAP and pandysautonomia patients showed significant anemia comparable with the severity of the autonomic dysfunctions. Shy-Drager patients exhibited mild anemia. However, in ALS patients, no such anemia was recognized at all even in the end stage of this disease. In pandysautonomia patients, hypoplastic bone marrow was recognized, which was quite consistent with the data previously reported in FAP patients. Human recombinant erythropoietin improved orthostatic hypotension as well as anemia in 4 FAP patients. These results suggest that autonomic dysfunction may be deeply connected with erythropoiesis.