Cellular-Interstitial Water Exchange and Its Effect on the Determination of Contrast Agent Concentration In Vivo: Dynamic Contrast-Enhanced MRI of Human Internal Obturator Muscle
Cellular-Interstitial Water Exchange and Its Effect on the Determination of Contrast Agent Concentration In Vivo: Dynamic Contrast-Enhanced MRI of Human Internal Obturator Muscle
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DOI：
10.1002/mrm.21748
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Stanisz, Greg J.
中科院分区：
文献类型：
--
作者：
Buckley, David L.;Kershaw, Lucy E.;Stanisz, Greg J.
本研究的目的是评估细胞-间质水交换对使用快速动态增强磁共振成像(DCE)获得的示踪剂动力学参数的估计的影响。使用三种水交换模式：无交换(NX)、快速交换限制(FXL)和中间速率(快门速度[SS])，对6名患者的内闭孔肌数据进行了检查。结合额外的多翻转角(FA)数据，还使用了完全两池交换模型。使用NX模型得到的结果(转移常数，K-Trans=0.049+/-0.027分钟(-1)，表观间质体积，v=0.14+/-0.04)略高于使用FXL模型(K-Trans=0.045+/-0.025分钟(-1)，v=0.13 0.04)，但在这些参数估计对中，有三分之二的误差条重叠。在一半的患者中，使用SS模型获得的K-tras和v(E)的估计值超过了使用NX模型获得的估计值，并且许多估计值，包括所有水在细胞内的停留时间t(0)的估计值都是不精确的。使用完整的两池模型得到的结果介于使用FXL和NX模型得到的结果之间，t(1)的估计也不精确。结果表明，使用临床相关的DCE-MRI获得的数据是交换不敏感的，不适合于评估细胞-间质水交换。《医学评论》60：1011-1019,2008。(C)2008年Wiley-Liss，Inc.
The purpose of this study was to assess the effects of cellular-interstitial water exchange on estimates of tracer kinetics parameters obtained using rapid dynamic contrast-enhanced (DCE) MRI. Data from the internal obturator muscle of six patients were examined using three models of water exchange: no exchange (NX), fast exchange limit (FXL), and intermediate rate (shutter-speed [SS]). In combination with additional multiple flip angle (FA) data, a full two-pool exchange model was also used. The results obtained using the NX model (transfer constant, K-trans = 0.049 +/- 0.027 min(-1), apparent interstitial volume, v. = 0.14 +/- 0.04) were marginally higher than those obtained using the FXL model (K-trans = 0.045 +/- 0.025 min(-1), v. = 0.13 0.04), but the error bars overlapped in two-thirds of these parameter estimate pairs. Estimates of K-trans and v(e) obtained using the SS model exceeded those obtained using the NX model in half the patients, and many estimates, including all those of intracellular residence time of water, t(0), were imprecise. Results obtained using the full two-pool model fell between those obtained using FXL and NX models, and estimates of t(1) were also imprecise. The results suggest that data obtained using clinically relevant DCE-MRI are exchange-insensitive and unsuitable for the assessment of cellular-interstitial water exchange. Magn Reson Med 60:1011-1019, 2008. (C) 2008 Wiley-Liss, Inc.