Effect of a bonding agent on in vitro biochemical activities of remineralizing resin-based calcium phosphate cements
Effect of a bonding agent on in vitro biochemical activities of remineralizing resin-based calcium phosphate cements
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DOI：
10.1016/j.dental.2008.02.004
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发表时间：
2008-09-01
期刊：
影响因子：
5
通讯作者：
Flaim, Glenn M.
中科院分区：
文献类型：
--
作者：
Dickens, Sabine H.;Flaim, Glenn M.
目标.为了测试基于树脂的Ca-PO 4离子释放水泥或具有用于改善粘附的酸性粘合剂的涂层中的氟化物是否损害水泥的再矿化潜力。配制不含氟化物的骨水泥（骨水泥A）或含氟化物的骨水泥（骨水泥B）。治疗组为A =骨水泥A; A2 =骨水泥A +粘合剂; B =骨水泥B; B2 =骨水泥B +粘合剂。钙，磷酸盐和氟离子的唾液样溶液（SLS）的释放测定从硬化水泥盘没有或有涂层的粘合剂。为了再矿化，在离体人磨牙的牙本质中制备两个洞并脱矿。一个洞接受复合树脂（对照）;另一个接受治疗A、A2、B或B2。在SLS中孵育6周后，切下180 μ m的横截面。通过横向显微放射照相术比较粘固剂组和对照组牙本质的密度，确定再矿化百分比。再矿化百分比（平均值+/- S.D.）A（39 +/- 14）= B（37 +/- 18），A2（23 +/- 13），B2（14 +/- 7）。双因素方差分析（ANOVA）和Holm-Sidak检验显示，粘合剂的存在具有显著影响（p < 0.05），但氟化物的影响不显著（p > 0.05）。所有组的离子溶液浓度相对于二水磷酸氢钙和氟化钙显示出欠饱和，而氟磷灰石和羟基磷灰石显示出过饱和，这表明正的再矿化潜力。与对照相比，所有处理均导致矿物质增加。粘合剂的存在对再矿化产生负面影响。(c)2008年，牙科材料学院。由爱思唯尔有限公司出版。保留所有权利。
Objectives. To test whether fluoride in a resin-based Ca-PO4 ion releasing cement or coating with an acidic bonding agent for improved adhesion compromised the cement remineralization potential.Methods. Cements were formulated without fluoride (Cement A) or with fluoride (Cement B). The treatment groups were A = Cement A; A2 = Cement A + bonding agent; B = Cement B; B2 = Cement B + bonding agent. The calcium, phosphate, and fluoride ion release in saliva-like solution (SLS) was determined from hardened cement disks without or with a coating of bonding agent. For the remineralization, two cavities were prepared in dentin of extracted human molars and demineralized. One cavity received composite resin (control); the other received treatment A, A2, B or B2. After 6 week incubation in SLS, 180 mu m cross-sections were cut. The percentage remineralization was determined by transverse microradiography comparing the dentin mineral density under the cement to that under the control.Results. The percentage of remineralization (mean +/- S.D.) was A (39 +/- 14) = B (37 +/- 18), A2 (23 +/- 13), B2 (14 +/- 7). TWo-way analysis of variance (ANOVA) and Holm-Sidak test showed a significant effect from the presence of bonding agent (p < 0.05), but not from fluoride (p > 0.05). The ion solution concentrations of all groups showed undersaturation with respect to dicalcium phosphate dihydrate and calcium fluoride and supersaturation for fluorapatite and hydroxyapatite suggesting a positive remineralization potential.Significance. Compared to the control all treatments resulted in mineral increase. The remineralization was negatively affected by the presence of the bonding agent. (c) 2008 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.