Serum Fatty Acids and Cardiovascular Risk Factors in Sudden Sensorineural Hearing Loss: A Case-Control Study
Serum Fatty Acids and Cardiovascular Risk Factors in Sudden Sensorineural Hearing Loss: A Case-Control Study
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DOI：
10.1177/000348941011900203
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发表时间：
2010-02-01
影响因子：
1.4
通讯作者：
Lippa, Silvio
中科院分区：
文献类型：
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作者：
Cadoni, Gabriella;Scorpecci, Alessandro;Lippa, Silvio
目的：我们分析了突发性感音神经性听力损失（SSNHL）与血清脂肪酸水平之间的关系。总胆固醇、低密度脂蛋白 (LDL) 和抗氧化剂辅酶 Q10。 方法：43 名 SSNHL 患者和 43 名健康受试者参加了该研究。主要结果指标是脂肪酸、辅酶 Q10、总胆固醇和 LDL 的血清水平。结果：基于单变量逻辑回归分析。总胆固醇（p < 0.001）、低密度脂蛋白（p = 0.024）、山萮酸（p < 0.001）、二十二碳六烯酸（p < 0.001）水平较高。亚麻酸（p = 0.017）和油酸（p < 0.001）以及低水平的辅酶 Q10（p < 0.001）和神经酸（p < 0.001）与所有 SSNHL 风险升高相关。石油多元分析。只有高胆固醇血症 (p = 0.15) 以及低水平的辅酶 Q10 (p = 0.02) 和神经酸 (p = 0.005) 与 SSNHL 显着相关。结论：这是首次报道低血清神经酸水平作为 SSNHL 的独立危险因素。考虑到高胆固醇血症、高血清 LDL 水平和低血清抗氧化剂辅酶 Q10 水平也与 SSNHL 相关。我们假设饱和脂肪酸可能在决定部分 SSNHL 患者的代谢异常状态中发挥作用。一起。这些发现表明，不仅仅是总胆固醇和低密度脂蛋白水平。而且还进行脂肪酸测定，可能有助于识别 SSNHL 患者的心血管危险因素。
Objectives: We analyzed the relationships between sudden sensorineural hearing loss (SSNHL) and serum levels of fatty acids. total cholesterol, low-density lipoproteins (LDLs), and the antioxidant coenzyme Q10.Methods: Forty-three patients with SSNHL and 43 healthy subjects were enrolled in the study. The main outcome measures were serum levels of fatty acids, coenzyme Q10, total cholesterol, and LDLs.Results: On univariate logistic regression analysis. high levels of total cholesterol (p < 0.001), LDLs (p = 0.024), behenic acid (p < 0.001), docosahexaenoic acid (p < 0.001). linolenic acid (p = 0.017) and oleic acid (p < 0.001) and low levels of coenzyme Q10 (p < 0.001) and nervonic acid (p < 0.001) were associated with all elevated risk of SSNHL. Oil Multivariate analysis. Only hypercholesterolemia (p = 0.15) and low levels of coenzyme Q10 (p = 0.02) and nervonic acid (p = 0.005) were significantly associated with SSNHL.Conclusions: This is the first report of low serum levels of nervonic acid as an independent risk factor for SSNHL. Considering that hypercholesterolemia, high serum levels of LDL, and low serum levels of the antioxidant coenzyme Q10 were associated with SSNHL as well. we hypothesize that saturated fatty acids may play a role in determining the dysmetabolic state in a subset of SSNHL patients. Together. these findings suggest that not only total cholesterol and LDL levels. but also fatty acid determination, may help identify SSNHL patients with cardiovascular risk factors.