Synthesis of Monofluoromethylthioesters from Aldehydes
Synthesis of Monofluoromethylthioesters from Aldehydes
复制标题
由醛合成单氟甲基硫酯
DOI：
10.1002/adsc.201800136
复制
发表时间：
2018-05-02
影响因子：
5.4
通讯作者：
Wang, Yong-Qiang
中科院分区：
文献类型：
--
作者：
Guo, Shi-Huan;Wang, Meng-Yue;Wang, Yong-Qiang
本文报道了一种由醛直接合成单氟甲硫酯的有效方法。本发明的合成方法反应条件温和，官能团耐受性好，底物范围广，特别是反应中无金属参与。该方法有可能成为高级合成中间体后期功能化的重要工具，并可能在药物化学中找到许多应用。
A direct and efficient approach to the synthesis of monofluoromethylthioesters from aldehydes has been developed. The synthetic method features mild reaction conditions, good tolerance of functional groups, a broad substrate scope, and especially no metal involved in the reaction. The approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates, and may find many applications in medicinal chemistry.