Inflammatory and autoimmune complications of common variable immune deficiency
Inflammatory and autoimmune complications of common variable immune deficiency
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DOI：
10.1016/j.autrev.2005.10.002
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发表时间：
2006-02-01
影响因子：
13.6
通讯作者：
Cunningham-Rundles, C
中科院分区：
文献类型：
--
作者：
Knight, AK;Cunningham-Rundles, C
常见变异性免疫缺陷（CVID）除了复发性感染外，还与自身免疫和炎症并发症有关。最常见的疾病是特发性血小板减少性紫癜、自身免疫性溶血性贫血、结节样肉芽肿病和胃肠道炎症。IVIG给药可降低感染频率，但并不总是能预防自身免疫或炎症。TNF拮抗剂和抗CD 20免疫调节剂在少数患者中显示出CVID的一些疗效;需要进一步的对照研究来确定免疫缺陷背景下这些疾病的最佳管理。(c)2005 Elsevier B. V.保留所有权利。
Common variable immune deficiency (CVID) is associated with autoimmune and inflammatory complications in addition to recurrent infections. The most common conditions are idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, sarcoid-like granulomatous disease and gastrointestinal inflammation. IVIG administration reduces the frequency of infections, but does not always prevent autoimmunity or inflammation. TNF antagonists and anti-CD20 immunomodulators have shown some efficacy in CVID in a few patients; further controlled studies are needed to determine the best management of these conditions in the setting of immunodeficiency. (c) 2005 Elsevier B.V. All rights reserved.