Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.
Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.
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DOI：
10.1038/ncomms12422
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发表时间：
2016-08-12
影响因子：
16.6
通讯作者：
Adams RH
中科院分区：
文献类型：
--
作者：
Chen Q;Zhang H;Liu Y;Adams S;Eilken H;Stehling M;Corada M;Dejana E;Zhou B;Adams RH
血管壁的壁细胞，即周细胞和血管平滑肌细胞，对血管的完整性至关重要。这些细胞的发育来源和在心脏中控制其祖细胞的分子机制仅部分了解。在这里，我们表明，内皮细胞是周细胞和血管平滑肌细胞在小鼠胚胎心脏的祖细胞。内皮细胞经历内皮-间充质转化并转化为表达血小板源性生长因子受体PDGFRα和PDGFRβ的原始间充质祖细胞。这些祖细胞迁移到心肌中，分化并组装冠状血管壁，这需要涉及Frizzled 4、β-连环蛋白和内皮细胞衍生的Wnt配体的典型Wnt信号传导。我们的研究结果确定了一个新的和意想不到的冠状动脉壁细胞的祖细胞群体与心脏功能和疾病状况的潜在相关性。 周细胞和血管平滑肌细胞对功能性血管至关重要，但这些细胞的发育来源并不完全清楚。在这里，作者表明，内皮细胞引起心脏壁细胞，这是由Wnt信号控制。
Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial–mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFRα and PDGFRβ. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, β-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions. Pericytes and vascular smooth muscle cells are crucial for functional blood vessels, but the developmental sources of these cells are incompletely understood. Here, the authors show that endocardial endothelial cells give rise to cardiac mural cells, which are controlled by Wnt signalling.