Cadmium, a metallic inhibitor of antibody-mediated immunity in mice.
Cadmium, a metallic inhibitor of antibody-mediated immunity in mice.
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镉，一种小鼠抗体介导免疫的金属抑制剂。
DOI：
10.1016/0013-9351(78)90042-7
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发表时间：
1978
影响因子：
8.3
通讯作者：
L. Chang
中科院分区：
文献类型：
--
作者：
B. Bozelka;P. Burkholder;L. Chang
B10-A-2R小鼠注射绵羊红细胞后，长期给予氯化镉可严重抑制脾中免疫球蛋白G和免疫球蛋白M空斑形成细胞(PFC)的出现，并延缓PFC的出现。停药后至少1个月的恢复期，IgM PFC未见增加，而Ig G PFC仅有轻微增加。在中毒的小鼠中也发现了明显的镉诱导的脾肿大。应用免疫黏附和玫瑰花环技术以及免疫荧光技术研究这些脾的细胞形态表明，导致脾大小增加的最主要的细胞类型是Fc和补体受体以及表面或胞浆免疫球蛋白。未发现多形性细胞和巨噬细胞群体对观察到的增生有显著影响。
Chronic administration of cadmium chloride to B10-A-2R mice was discovered to severely depress the numbers and to delay the onset of appearance of splenic IgG and IgM plaque-forming cells (PFC) following injection of sheep erythrocytes. A recovery period of at least 1 month following cessation of administration of CdCl2resulted in no increase in IgM PFC and only a minimal increase in IgG PFC. An apparent cadmium-induced splenomegaly was also noted in the intoxicated mice. Application of immune adherence and rosetting techniques as well as immunofluorescence to study the cellular morphology of these spleens indicated that the cell type most responsible for the increased spleen size had Fc and complement receptors as well as surface or cytoplasmic immunoglobulins. Populations of polymorphs and macrophages were not found to significantly contribute to the hyperplasia observed.