Evaluation of Antidiarrheal Activity of Aerial Parts of Vinca major in Experimental Animals
Evaluation of Antidiarrheal Activity of Aerial Parts of Vinca major in Experimental Animals
复制标题
长春花地上部分对实验动物的止泻活性评价
DOI：
--
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dewas Naka
中科院分区：
文献类型：
--
作者：
M. Rajput;Veena A. Nair;A. Chauhan;Hitesh Jawanjal;Vikramsingh Dange;R. Nagar;P. Kakkad;Dewas Naka
2摘要：本研究以大鼠为实验动物，对大叶草地上部分乙醇提取物进行了抗炎活性评价。采用蓖麻油致小鼠腹泻、蓖麻油和硫酸镁致小鼠小肠积血、炭粉法测定小鼠胃肠动力的方法，研究了大叶黄杨地上部分乙醇提取物的抗腹泻作用。将提取物（250、500和1000 mg/kg，p.o.）测定蓖麻油致腹泻小鼠的潜伏期、大便次数。使用木炭粉、蓖麻油和硫酸镁诱导的肠池试验（500 mg/kg，p.o.）进行了。这些结果表明，在500 mg/kg，p.o.，蓖麻油引起的腹泻、炭餐试验中的蠕动、蓖麻油和硫酸镁引起的肠液分泌物，表明其具有抗腹泻活性。实验结果表明，黄蜀葵花主要地上部分的乙醇提取物具有一定的抗真菌活性。
2 Abstract: In the present study, the ethanolic extract from the aerial parts of Vinca major was evaluated for the antidiarrheal activity in rats. The effects of the ethanol extract from the aerial parts of Vinca major on castor oil induced diarrhea, castor oil and magnesium sulfate induced enteropooling, gastrointestinal motility test using charcoal meal methods were examined. This extract (250, 500 and, 1000 mg/kg, p.o.) was assayed on the latent periods, fecal frequencies in castor oil induced diarrhea. Gastrointestinal transit using charcoal meal, castor oil and magnesium sulfate induced enteropooling assays (500 mg/kg, p.o.) were conducted. These results suggested that the significant (p<0.05) reduction of the fecal output was observed at a dose of 500 mg/kg, p.o., in castor oil induced diarrhea, peristaltic movements in charcoal meal test, intestinal fluid secretions in castor oil and magnesium sulphate induced enteropooling, indicating its antidiarrheal activity. The results provide evidence that the ethanolic extract from Vinca major aerial parts possess antidiarrheal activities.