HLA-A AND DPB1 LOCI CONFER SUSCEPTIBILITY TO GRAVES-DISEASE
HLA-A AND DPB1 LOCI CONFER SUSCEPTIBILITY TO GRAVES-DISEASE
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DOI：
10.1016/0198-8859(92)90101-r
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发表时间：
1992-11-01
期刊：
影响因子：
2.7
通讯作者：
SASAZUKI, T
中科院分区：
文献类型：
--
作者：
DONG, RP;KIMURA, A;SASAZUKI, T
为探讨Graves病发病机制中的HLA连锁遗传因素，采用PCR-SSOP方法，对76例Graves病患者和317例健康对照者进行了HLA-A、B、C、DR和DQ特异性血清学分型和HLA-DPB 1等位基因DNA分型检测。HLA-A2、B46、Cw 11和DPB 1 *0501的频率增高，HLA-A24、B7、Bw 52和DR 1的频率降低。当应用校正的p值（P（c））时，患者中HLA-A2和DPB 1 *0501的频率增加具有统计学意义（分别为p（c）< 0.02和p（c）< 0.002）。在DPB 1 *0501和/或HLA-A2阳性的个体中计算发展疾病的风险的OR，并且在具有DPB 1 *0501和HLA-A2的个体中观察到最高的OR（10.5）。这一观察结果表明，HLA II类等位基因（DPB 1 *0501）和HLA I类等位基因（HLA-A2）在Graves病的发病机制中协同参与。
To investigate HLA-linked genetic factors involved in the pathogenesis of Graves' disease, 76 patients and 317 healthy controls in the Japanese population were examined for HLA-A, B, C, DR, and DQ specificities by serologic typing and for HLA-DPB1 alleles by DNA typing by using the PCR-SSOP method. The frequencies of HLA-A2, B46, Cw11, and DPB1*0501 were increased and those of HLA-A24, B7, Bw52, and DR1 were decreased in the patients. The increased frequencies of HLA-A2 and DPB1*0501 in the patients were statistically significant when the corrected p value (P(c)) was applied (p(c) < 0.02 and p(c) < 0.002, respectively). ORs for a risk to develop the disease were calculated among individuals positive for DPB1*0501 and/or HLA-A2, and the highest OR (10.5) was observed in individuals possessed both DPB1*0501 and HLA-A2. This observation suggests a synergic involvement of a HLA class II allele (DPB1*0501) and an HLA class I allele (HLA-A2) in the pathogenesis of Graves' disease.