Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma
Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma
复制标题
NKD1在人原发性肝细胞癌中的表达模式及临床病理意义。
DOI：
10.1111/apm.12360
复制
发表时间：
2015-04-01
期刊：
影响因子：
2.8
通讯作者：
Wang, Xiao-Min
中科院分区：
文献类型：
--
作者：
Zhang, Sheng;Li, Jie;Wang, Xiao-Min
据报道，NKD1是典型Wnt/-catenin通路的拮抗剂。然而，关于NKD1在人类肝细胞癌（HCC）中的表达模式的信息很少。本研究旨在探讨NKD1在HCC中的临床病理意义及表达模式。Western blot检测69对HCC癌/癌旁非癌组织中NKD1蛋白的表达。对58例肝细胞癌进行免疫组化研究，综合临床资料。将NKD1蛋白表达分为正常组和低表达组，评价NKD1蛋白表达与临床病理因素的相关性。Western blot结果显示，癌组织中NKD1蛋白水平明显低于相应的正常组织(p
It has been reported that NKD1 was an antagonist of the canonical Wnt/-catenin pathway. While there is little information regarding NKD1 expression pattern in human hepatocellular carcinoma (HCC). The aim of this study was to investigate the clinicopathologic significance and expression pattern of NKD1 in HCC. NKD1 protein expressions in 69 paired HCC cancer/adjacent non-cancerous tissues were detected by Western blot. Immunohistochemical studies were performed on 58 cases of HCC with integrated clinical information. NKD1 protein expression was divided into normal and low expression group and correlations between NKD1 protein expression and clinicopathologic factors were then evaluated. Western blot results showed that NKD1 protein levels were significantly lower in cancerous tissues compared with corresponding normal tissue (p