Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments.
Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments.
复制标题
DOI:
10.1093/bioinformatics/btv146
复制
发表时间:
2015-07-15
期刊:
影响因子:
--
通讯作者:
Vitek O
中科院分区:
文献类型:
--
作者:
Bemis KD;Harry A;Eberlin LS;Ferreira C;van de Ven SM;Mallick P;Stolowitz M;Vitek O
Cardinal is an R package for statistical analysis of mass spectrometry-based imaging (MSI) experiments of biological samples such as tissues. Cardinal supports both Matrix-Assisted Laser Desorption/Ionization (MALDI) and Desorption Electrospray Ionization-based MSI workflows, and experiments with multiple tissues and complex designs. The main analytical functionalities include (1) image segmentation, which partitions a tissue into regions of homogeneous chemical composition, selects the number of segments and the subset of informative ions, and characterizes the associated uncertainty and (2) image classification, which assigns locations on the tissue to pre-defined classes, selects the subset of informative ions, and estimates the resulting classification error by (cross-) validation. The statistical methods are based on mixture modeling and regularization. Contact: o.vitek@neu.edu Availability and implementation: The code, the documentation, and examples are available open-source at www.cardinalmsi.org under the Artistic-2.0 license. The package is available at www.bioconductor.org.
登录
查看更多内容
影响因子:
5.7
作者:
Tibshirani, R;Hastie, T;Chu, G
通讯作者:
Chu, G
影响因子:
3.3
作者:
Schramm, Thorsten;Hester, Alfons;Roempp, Andreas
通讯作者:
Roempp, Andreas
影响因子:
3
作者:
Yang C;He Z;Yu W
通讯作者:
Yu W
影响因子:
3
作者:
Mantini D;Petrucci F;Pieragostino D;Del Boccio P;Di Nicola M;Di Ilio C;Federici G;Sacchetta P;Comani S;Urbani A
通讯作者:
Urbani A
影响因子:
5.8
作者:
Alexandrov, Theodore;Kobarg, Jan Hendrik
通讯作者:
Kobarg, Jan Hendrik