Endothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in rats
Endothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in rats
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DOI：
10.1016/j.cardiores.2005.04.020
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发表时间：
2005-09-01
影响因子：
10.8
通讯作者：
Kolettis, TM
中科院分区：
文献类型：
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作者：
Baltogiannis, GG;Tsalikakis, DG;Kolettis, TM
目的：内皮素-1（ET-1）在急性心肌梗死（MI）期间产生增加，并可能导致室性心动过速（VT）和室颤（VF）的发生。然而，ET-1受体阻滞剂的抗心肌梗死作用，检查后不久，一直存在争议。在本研究中，我们检查了MI后前24小时内此类治疗对VT/VF的影响。35只Wistar大鼠（223 +/- 22 g）随机分配至ET-1受体-A（ETA）拮抗剂BQ-123组（0.4mg/kg，BQ-123组，n=17）或生理盐水（对照组，n=18），并进行冠状动脉结扎。使用植入的遥测系统连续记录MI后24小时的单导联心电图，并分析VT/VF发作。在基线、治疗后5分钟和MI后24小时，从左（LV）和右（RV）心室心外膜获得单相动作电位（MAP）记录。对照组VT/VF发作次数为15.94 +/- 19.35次/h/大鼠，BQ-123组为1.66 +/- 2.22次（p=0.010），导致给药动物的动物死亡率较低（p=0.030）。对照组的平均发作持续时间为7.40 ± 7.16 s，BQ-123组为2.30 ± 1.37 s（p=0.011）。VT/VF在MI后1、5和6小时内下降最大。在对照组中，LV MAP持续时间增加24它后MI，显示增加的心跳到心跳的变化，但保持不变的BQ-123 group.Conclusion：急性ETA阻滞减少VT/VF的发病率在第一个24小时后MI大鼠，通过减少复极的离散度。(c)2005年欧洲心脏病学会。Elsevier B. V.出版，保留所有权利。
Objective: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia, (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-I receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI.Methods: Thirty-five Wistar rats (223 +/- 22 g) were randomly allocated to either the ET-I receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI.Results: There were 15.94 +/- 19.35 episodes/h/rat of VT/VF in the control group and 1.66 +/- 2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40 +/- 7.16 s for the control group and 2.30 +/- 1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 It post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group.Conclusion: Acute ETA blockade reduces the incidence of VT/VF during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.