ACh differentially modulates voltage-gated K channels in glomus cells between DBA/2J and A/J strains of mice.
ACh differentially modulates voltage-gated K channels in glomus cells between DBA/2J and A/J strains of mice.
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ACh 差异调节 DBA/2J 和 A/J 品系小鼠的血管球细胞中的电压门控 K 通道。
DOI：
10.1007/978-1-4419-9280-2_34
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发表时间：
2003
影响因子：
--
通讯作者：
Shirahata,Machiko
中科院分区：
文献类型：
--
作者：
Yamaguchi,Shigeki;Higashi,Tomoko;Hori,Yuichi;Shirahata,Machiko
个体之间的缺氧通气反应（HVR）差异很大（Eiseleet al,1992; Vizeket al,1987; Weilet al,1970），并且遗传因素对这些差异有显着贡献（Kawakamiet al,1982; Nishimuraet al,1991）。使用几种近交系小鼠的研究表明，遗传决定因素明显影响 HVR (Tankersleyet al,1994) DBA/2J 小鼠表现出最高的 HVR，而 A/J 小鼠表现出最低的 HVR。这些数据表明，控制缺氧通气反应的系统中存在基因调节差异。主要的缺氧化学传感器是颈动脉体。最近，我们发现 DBA/2J 和 A/J 小鼠之间血管球细胞的形态和功能差异（Yamaguchiet al,2003）。 DBA/2J小鼠的颈动脉体比A/J小鼠含有更多的血管球细胞，并且DBA/2J小鼠中比A/J小鼠更多的血管球细胞响应ACh而增加细胞内Ca2+。
The hypoxic ventilatory response (HVR) among individuals varies widely (Eiseleet al,1992; Vizeket al,1987; Weilet al,1970) and genetic factors significantly contribute to these variations (Kawakamiet al,1982; Nishimuraet al,1991). A study using several inbred strains of mice indicates that genetic determinants apparently influence the HVR (Tankersleyet al,1994) DBA/2J mice demonstrated the highest HVR and the A/J mice the lowest HVR. These data suggest that genetically regulated differences exist in the system controlling the hypoxic ventilatory response. A major hypoxic chemosensor is the carotid body. Recently, we have found morphological and functional differences in glomus cells between DBA/2J and A/J mice (Yamaguchiet al,2003). The carotid body of DBA/2J mice contain more glomus cells than that of the A/J mice, and more glomus cells in DBA/2J mice increase intracellular Ca2+in response to ACh than those in A/J mice.