Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits
Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits
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DOI：
10.1037/0735-7044.110.1.86
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发表时间：
1996-02-01
影响因子：
1.9
通讯作者：
Boon, F
中科院分区：
文献类型：
--
作者：
Cain, DP;Saucier, D;Boon, F
N -甲基- D -天冬氨酸（NMDA）受体拮抗剂会干扰水迷宫的习得，并导致感觉运动障碍。在对雄性大鼠进行的详细行为分析中发现，NMDA拮抗剂DL - 2 - 氨基膦酰基戊酸（APV）会在迷宫测试所需的行为中引起感觉运动障碍，并且这些障碍与隐藏平台和可见平台版本的迷宫习得障碍相关。行为障碍包括趋触性游泳、游过平台并偏离平台、异常游泳行为以及活动过度。熟悉任务所涉及行为策略的大鼠在APV作用下表现正常。这些结果与已知的NMDA受体在感觉运动机制中的作用一致，并表明药物诱导的感觉运动障碍导致了未经训练的大鼠习得分数较低。NMDA可能有助于水迷宫中的空间学习，但似乎并非必不可少。
N-methyl-D-aspartate (NMDA) receptor antagonists disrupt acquisition of the water maze and cause sensorimotor disturbances. In a detailed behavioral analysis in male rats, it was found that the NMDA antagonist DL-2-aminophosphonovaleric acid (APV) caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under APV. The results are consistent with the known role of NMDA receptors in sensorimotor mechanisms and suggest that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA may contribute to but does not appear to be essential for spatial learning in the water maze.