The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.
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DOI：
10.3389/fimmu.2017.01124
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发表时间：
2017
影响因子：
7.3
通讯作者：
Lal G
中科院分区：
文献类型：
--
作者：
Paul S;Lal G
自然杀伤（NK）细胞是先天性免疫细胞，其对生理应激细胞（如肿瘤细胞和病毒感染的细胞）显示出强的细胞溶解功能。NK细胞显示出广泛的组织分布和表型变异性。NK细胞表达几种活化和抑制受体，其识别靶细胞上蛋白质的改变表达并控制细胞溶解功能。NK细胞已在几项临床试验中用于控制肿瘤生长。然而，结果仅在血液恶性肿瘤中令人鼓舞，但在实体瘤中不是很有希望。越来越多的证据表明，肿瘤微环境调节NK细胞的表型和功能。本文就NK细胞的表型及其效应功能以及肿瘤微环境对NK细胞效应功能和杀伤功能的影响作一综述。我们还总结了过去使用的各种基于NK细胞的免疫策略以及改善NK细胞功能以获得更好临床结果的可能性。
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells and control the cytolytic function. NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in hematological malignancies but not very promising in solid tumors. Increasing evidence suggests that tumor microenvironment regulate the phenotype and function of NK cells. In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on effector and cytolytic function of NK cells. We also summarized various NK cell-based immunotherapeutic strategies used in the past and the possibilities to improve the function of NK cell for the better clinical outcome.